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Found 365 with Last Name = 'scheunemann' and Initial = 'm'

Vesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL

BDBM50039623((2R,3R)-5-Amino-3-(4-phenyl-piperidin-1-yl)-1,2,3,...)

Ki: 0.0130nMAssay Description:Displacement of (-)-[3H]vesamicol from VAChT in Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair

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Vesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL

BDBM50039613((2R,3R)-3-(4-Phenyl-piperidin-1-yl)-1,2,3,4-tetrah...)

Ki: 0.0550nMAssay Description:Displacement of (-)-[3H]vesamicol from VAChT in Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair

UniProtKB/SwissProt
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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster

Curated by ChEMBL

BDBM50259004(1'-[4-Fluorobenzyl]-3H-spiro[[2]benzofuran-1,4'pip...)

Ki: 0.180nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair

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Neuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL

BDBM50393252(CHEMBL2151570)

Ki: 0.220nMAssay Description:Displacement of [3H]A-585539 from alpha7 nAChR in human cerebral cortex membranes after 75 mins by scintillation countingMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL

BDBM50218673(2-(2-((dimethylamino)methyl)-4-fluorophenylthio)-5...)

Ki: 0.270nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brainMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL

BDBM50218674(3-amino-4-(2-((dimethylamino)methyl)-4-fluoropheny...)

Ki: 0.280nMAssay Description:Displacement of [3H]citalopram from SERT in rat brainMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Vesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL

BDBM50095010(CHEMBL264437)

Ki: 0.340nMAssay Description:Displacement of (-)-[3H]vesamicol from VAChT in Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair

UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL

BDBM50218670(5-chloro-2-(2-((dimethylamino)methyl)-4-fluorophen...)

Ki: 0.350nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brainMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)

Ki: 0.380nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)

Ki: 0.380nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Cannabinoid receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50600964(CHEMBL5181335)

Ki: 0.400nMAssay Description:Displacement of [3H]-WIN55212-2 from human CB2 receptor transfected in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)

Ki: 0.420nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)

Ki: 0.420nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Abx Advanced Biochemical Compounds

Curated by ChEMBL

BDBM86522(CAS_325715-02-4 | Indiplon)

Ki: 0.450nMAssay Description:Displacement of [3H]Ro15-1788 from GABAA alpha1 receptor in Sprague-Dawley rat cerebral cortex membraneMore data for this Ligand-Target Pair

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Gamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Abx Advanced Biochemical Compounds

Curated by ChEMBL

BDBM86522(CAS_325715-02-4 | Indiplon)

Ki: 0.550nMAssay Description:Displacement of [3H]Ro15-1788 from GABAA alpha-1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair

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Cannabinoid receptor 1(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50600961(CHEMBL5198892)

Ki: 0.600nMAssay Description:Displacement of [3H]-SR141716A from recombinant human CB1 receptor expressed in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair

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Cannabinoid receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50600966(CHEMBL5205138)

Ki: 0.600nMAssay Description:Inhibition of human CB2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL

BDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)

Ki: 0.620nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brainMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM50010588((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)

Ki: 0.730nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)

Ki: 0.730nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster

Curated by ChEMBL

BDBM50259001(1'-(4-Fluorobenzyl)-3-methoxy-3H-spiro[[2]benzofur...)

Ki: 0.790nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster

Curated by ChEMBL

BDBM50258915(1'-(4-Fluorobenzyl)-3H-spiro[[2]benzofuran-1,4'-pi...)

Ki: 0.860nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair

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Cannabinoid receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50600965(CHEMBL5182619)

Ki: 0.900nMAssay Description:Displacement of [3H]-WIN55212-2 from human CB2 receptor transfected in CHO-K1 cell membrane incubated for 90 mins by Liquid scintillation counter ana...More data for this Ligand-Target Pair

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Vesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL

BDBM50018094((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol |...)

Ki: 1nMAssay Description:Binding affinity to VAChT Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair

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Neuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Mahidol University

Curated by ChEMBL

BDBM92878(Quinuclidine analogue, 5)

Ki: 1nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster

Curated by ChEMBL

BDBM50108659(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)

Ki: 1.10nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair

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Vesicular acetylcholine transporter(Rattus norvegicus)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL

BDBM50039613((2R,3R)-3-(4-Phenyl-piperidin-1-yl)-1,2,3,4-tetrah...)

Ki: 1.30nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in PC12 cell membranes incubated for 2 hrs by liquid scintillation counting based competit...More data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster

Curated by ChEMBL

BDBM50258916(3-Allyl-1'-(4-fluorobenzyl)-3H-spiro[[2]benzofuran...)

Ki: 1.40nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair

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Cannabinoid receptor 1(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50600962(CHEMBL5186632)

Ki: 1.5nMAssay Description:Displacement of [3H]-SR141716A from recombinant human CB1 receptor expressed in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair

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Cannabinoid receptor 1(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50029958(CHEMBL3353439)

Ki: 1.70nMAssay Description:Displacement of [3H]-SR141716A from recombinant human CB1 receptor expressed in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM50010588((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)

Ki: 2.03nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)

Ki: 2.03nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL

BDBM50218671(2-(4-chloro-2-((dimethylamino)methyl)phenoxy)-5-fl...)

Ki: 2.06nMAssay Description:Displacement of [3H]citalopram from SERT in rat brainMore data for this Ligand-Target Pair

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL

BDBM50534298(CHEMBL4438684)

Ki: 2.30nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair

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Neuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL

BDBM50433470(CHEMBL2380928)

Ki: 2.5nMAssay Description:Displacement of [3H]-methyllycaconitine from human alpha7 nAChR transfected in human SH-SY5Y cells after 240 mins by liquid scintillation counting an...More data for this Ligand-Target Pair

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL

BDBM50534286(CHEMBL4453542)

Ki: 2.5nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL

BDBM50534287(CHEMBL4519018)

Ki: 2.60nMAssay Description:Binding affinity to alpha3beta4 nAChR (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
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Vesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL

BDBM50292907((+)-trans-(4-fluorophenyl)(1-(3-hydroxy-1,2,3,4-te...)

Ki: 2.70nMAssay Description:Displacement of (-)-[3H]vesamicol from VAChT in Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair

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Cannabinoid receptor 1(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50600942(CHEMBL5173419)

Ki: 2.90nMAssay Description:Displacement of [3H]-SR141716A from recombinant human CB1 receptor expressed in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL

BDBM50218675(3-amino-4-(2-((dimethylamino)methyl)-4-fluoropheno...)

Ki: 2.91nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brainMore data for this Ligand-Target Pair

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL

BDBM50500410(CHEMBL3745799)

Ki: 3.10nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair

PDB KEGG
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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster

Curated by ChEMBL

BDBM50259002(1'-(4-Fluorobenzyl)-3H-spiro[[2]benzofuran-1,4'-pi...)

Ki: 3.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair

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Cannabinoid receptor 1(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50600948(CHEMBL5199801)

Ki: 3.30nMAssay Description:Displacement of [3H]-SR141716A from recombinant human CB1 receptor expressed in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL

BDBM50534288(CHEMBL4472617)

Ki: 3.40nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair

PDB KEGG
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Cannabinoid receptor 1(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL

BDBM50600963(CHEMBL5183565)

Ki: 3.90nMAssay Description:Displacement of [3H]-SR141716A from recombinant human CB1 receptor expressed in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster

Curated by ChEMBL

BDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)

Ki: 3.90nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM50102006(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)

Ki: 4.10nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM50102005(2-[3-(5-Fluoro-1H-indol-3-yl)-propyl]-6-methoxy-1,...)

Ki: 4.11nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)

Ki: 4.38nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL

BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)

Ki: 4.38nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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PDB

3D Structure (crystal)

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Targets 17▿
- Sigma non-opioid intracellular receptor 1 63
- Vesicular acetylcholine transporter 62
- Sodium-dependent serotonin transporter 44
- Neuronal acetylcholine receptor subunit alpha-7 30
- Neuronal acetylcholine receptor subunit alpha-4/beta-2 27
- Cannabinoid receptor 1 26
- Cannabinoid receptor 2 24
- Neuronal acetylcholine receptor subunit alpha-3/beta-4 23
- Sodium-dependent dopamine transporter 20
- 5-hydroxytryptamine receptor 1A 12
- Sodium-dependent noradrenaline transporter 12
- Transporter 7
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 6
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 3
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A 2
- Gamma-aminobutyric acid receptor subunit alpha-1 2
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 2
- ...
Publications 10▿
- Eur J Med Chem 100: 50-67 (2015) 116
- ACS Med Chem Lett 7: 890-895 (2016) 76
- J Med Chem 65: 9034-9049 (2022) 50
- Bioorg Med Chem Lett 18: 4727-30 (2008) 36
- Bioorg Med Chem 16: 6364-70 (2008) 36
- Bioorg Med Chem Lett 17: 4991-5 (2007) 23
- Eur J Med Chem 107: 97-108 (2015) 13
- Bioorg Med Chem 17: 3630-41 (2009) 9
- Bioorg Med Chem 21: 2635-42 (2013) 4
- Bioorg Med Chem 16: 1184-94 (2008) 2
Institutions 9▿
- Institute Of Radiopharmaceutical Cancer Research 129
- Mahidol University 76
- Helmholtz-Zentrum Dresden-Rossendorf (Hzdr) 50
- Institut FüR InterdisziplinäRe Isotopenforschung 36
- Hadassah Hebrew University Hospital 36
- University Of Tours 23
- Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster 9
- Helmholtz-Zentrum Dresden-Rossendorf 4
- Abx Advanced Biochemical Compounds 2
Affinity: 0.013 to 6.8E+4 nM▿
- Ki 350
- IC50 15
- Affinity ≤ nM
Xtal structures: 3
Docked structures: 0
Catalog Cmpds: 18