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Found 199 with Last Name = 'schiavini' and Initial = 'p'
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of POP in Han/Wistar rat brain using Suc-Gly-Pro-AMC substrate incubated for 60 minsMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of poricne brain POP in expressed in Escherichia coli TOP10 competent cells pre-incubated for 2 hrs before Z-Gly-Pro-AMC substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of POP in bovine serum using Z-Gly-Pro-NH-Mec fluorimetric substrateMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180679(CHEMBL3817958)
Affinity DataKi:  0.75nMAssay Description:Inhibition of human POP by tight binding based Morrison equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.920nMAssay Description:Inhibition of human POP by tight binding based Morrison equation analysisMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180679(CHEMBL3817958)
Affinity DataKi:  1nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334458(CHEMBL1643901 | N-(3-Fluorobenzyl)-N-methyl-8-amin...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human POP using Z-Gly-Pro-7-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50026948((trans) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct...)
Affinity DataKi:  7.20nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180664(CHEMBL3818013)
Affinity DataKi:  10nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50175145(8-(2-aminoethyl)-N-(bis(4-fluorophenyl)methyl)-8-a...)
Affinity DataKi:  12.5nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334461(2-butyl-3-(4-chlorophenyl)-1-azabicyclo[2.2.2]oct-...)
Affinity DataKi:  14nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334459((1S,2S,3S,5R)-methyl 8-(3-iodoallyl)-3-p-tolyl-8-a...)
Affinity DataKi:  17nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  19nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50393843(CHEMBL2159748)
Affinity DataKi:  23nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180669(CHEMBL3818020)
Affinity DataKi:  33nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50026948((trans) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct...)
Affinity DataKi:  44nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180678(CHEMBL3819136)
Affinity DataKi:  46nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50026948((trans) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct...)
Affinity DataKi:  57nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(CHEMBL1643902 | N-(2-(3'-Fluorophenyl)ethyl)-N-met...)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(CHEMBL1643899 | N-(3-Fluorobenzyl)-8-aminopentacyc...)
Affinity DataKi:  198nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334459((1S,2S,3S,5R)-methyl 8-(3-iodoallyl)-3-p-tolyl-8-a...)
Affinity DataKi:  500nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  705nMAssay Description:Inhibition of muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334459((1S,2S,3S,5R)-methyl 8-(3-iodoallyl)-3-p-tolyl-8-a...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180668(CHEMBL3819096)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(CHEMBL1643902 | N-(2-(3'-Fluorophenyl)ethyl)-N-met...)
Affinity DataKi:  1.16E+3nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180667(CHEMBL3818815)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334458(CHEMBL1643901 | N-(3-Fluorobenzyl)-N-methyl-8-amin...)
Affinity DataKi:  1.57E+3nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  1.68E+3nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  1.83E+3nMAssay Description:Inhibition of muscarinic M5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(CHEMBL1643902 | N-(2-(3'-Fluorophenyl)ethyl)-N-met...)
Affinity DataKi:  2.07E+3nMAssay Description:Inhibition of alpha2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180681(CHEMBL3818902)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50175145(8-(2-aminoethyl)-N-(bis(4-fluorophenyl)methyl)-8-a...)
Affinity DataKi:  2.11E+3nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(CHEMBL1643899 | N-(3-Fluorobenzyl)-8-aminopentacyc...)
Affinity DataKi:  2.15E+3nMAssay Description:Inhibition of H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  2.29E+3nMAssay Description:Inhibition of muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  2.38E+3nMAssay Description:Inhibition of H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(CHEMBL1643899 | N-(3-Fluorobenzyl)-8-aminopentacyc...)
Affinity DataKi:  3.44E+3nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  3.62E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180665(CHEMBL3819346)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  4.42E+3nMAssay Description:Inhibition of H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(CHEMBL1643902 | N-(2-(3'-Fluorophenyl)ethyl)-N-met...)
Affinity DataKi:  4.45E+3nMAssay Description:Inhibition of H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  5.22E+3nMAssay Description:Inhibition of dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(CHEMBL1643899 | N-(3-Fluorobenzyl)-8-aminopentacyc...)
Affinity DataKi:  5.88E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  6.02E+3nMAssay Description:Inhibition of 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(CHEMBL1643902 | N-(2-(3'-Fluorophenyl)ethyl)-N-met...)
Affinity DataKi:  6.09E+3nMAssay Description:Inhibition of 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(CHEMBL1643900 | N-(2-(3'-Fluorophenyl)ethyl)-8-ami...)
Affinity DataKi:  6.98E+3nMAssay Description:Inhibition of 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(CHEMBL1643899 | N-(3-Fluorobenzyl)-8-aminopentacyc...)
Affinity DataKi:  7.16E+3nMAssay Description:Inhibition of dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180670(CHEMBL3819362)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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