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Found 751 with Last Name = 'shiau' and Initial = 'ak'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317611(4-(3,5-dichloropyridin-4-ylamino)-8-(3-(dimethylam...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317609(8-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317616(4-(3,5-dichloropyridin-4-ylamino)-8-(8-(dimethylam...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317610(9-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317615(4-(3,5-dichloropyridin-4-ylamino)-8-(7-(dimethylam...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317603(8-(cyclopentyloxy)-4-(3,5-dichloropyridin-4-ylamin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363262(CHEMBL1944717)
Affinity DataIC50:  5nMAssay Description:Inhibition of mouse iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363262(CHEMBL1944717)
Affinity DataIC50:  5nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317604(2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317614(4-(3,5-dichloropyridin-4-ylamino)-8-(6-(dimethylam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50356505(CHEMBL1911882)
Affinity DataIC50:  7nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319027((+/-)-3-(amino(2-(2-aminopyrimidin-4-yl)-3-methylb...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363270(CHEMBL1944884)
Affinity DataIC50:  10nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50356504(CHEMBL1911883)
Affinity DataIC50:  10nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM29241(quinolinone, 12)
Affinity DataIC50:  11nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363277(CHEMBL1945066)
Affinity DataIC50:  11nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363266(CHEMBL1944721)
Affinity DataIC50:  12nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363262(CHEMBL1944717)
Affinity DataIC50:  12nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363269(CHEMBL1944724)
Affinity DataIC50:  12nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363263(CHEMBL1944718)
Affinity DataIC50:  13nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363265(CHEMBL1944720)
Affinity DataIC50:  13nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363261(CHEMBL1944716)
Affinity DataIC50:  14nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363281(CHEMBL1945068)
Affinity DataIC50:  17nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317608(7-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50179869(CHEMBL203682 | N-methyl-N-[4-(2,2,2-trifluoro-1-hy...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide from LXRbeta by scintillation proximity assa...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319035((+/-)-4-(5-(1-aminobutyl)-3-methylbenzo[b]thiophen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319031((+/-)-4-(5-(amino(phenyl)methyl)-3-methylbenzo[b]t...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319026((+/-)-4-(5-(amino(3-methoxyphenyl)methyl)-3-methyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319025(3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiop...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319021(3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thio...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317613(4-(3,5-dichloropyridin-4-ylamino)-8-(5-(dimethylam...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363279(CHEMBL1944890)
Affinity DataIC50:  28nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319037((+/-)-4-(5-(1-amino-3-methylbutyl)-3-methylbenzo[b...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319029((+/-)--4-(5-(amino(3-chlorophenyl)methyl)-3-methyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363258(CHEMBL1944712)
Affinity DataIC50:  31nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363272(CHEMBL1944886)
Affinity DataIC50:  33nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50179869(CHEMBL203682 | N-methyl-N-[4-(2,2,2-trifluoro-1-hy...)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide from LXRalpa by scintillation proximity assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317607(6-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363260(CHEMBL1944715)
Affinity DataIC50:  43nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50327527(2-(4-bromophenyl)-N-((7-methoxy-2-(pyridin-4-yl)qu...)
Affinity DataIC50:  44nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317612(4-(3,5-dichloropyridin-4-ylamino)-8-(4-(dimethylam...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363270(CHEMBL1944884)
Affinity DataIC50:  46nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319030((+/-)--4-(5-(amino(m-tolyl)methyl)-3-methylbenzo[b...)
Affinity DataIC50:  50nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363273(CHEMBL1944887)
Affinity DataIC50:  53nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319022(3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thio...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Afraxis

Curated by ChEMBL
LigandPNGBDBM50363266(CHEMBL1944721)
Affinity DataIC50:  60nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319036((+/-)-4-(5-(1-amino-2-methylpropyl)-3-methylbenzo[...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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