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Found 373 with Last Name = 'silakari' and Initial = 'o'
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50394355(CHEMBL2159766)
Affinity DataKi:  9nMAssay Description:Inhibition of CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50394356(CHEMBL2159765)
Affinity DataKi:  100nMAssay Description:Inhibition of CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  520nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50050769(CHEMBL3318019)
Affinity DataKi:  560nMAssay Description:Binding affinity to human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataKi:  7.30E+3nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  8.10E+4nMAssay Description:Inhibition of forskolin-stimulated CFTR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM10512(CHEMBL194823 | N-{3-[(6-chloro-1,2,3,4-tetrahydroa...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50613673(CHEMBL1964259)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of human CDK1 using Biotinaminohexyl-Ala-Arg-Arg-Pro-Met-Ser-Pro-Lys-LysLys-Ala-CONH2 peptide as substrate incubated for 20 to 30 mins by ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50:  0.601nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094542(1,3-Diphenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrro...)
Affinity DataIC50:  0.701nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094539(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50462398(CHEMBL4249848)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of bovine erythrocyte AchE using acetylthiocholine iodide as substrate after 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50462402(CHEMBL4249379)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of bovine erythrocyte AchE using acetylthiocholine iodide as substrate after 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50126727((S)-4-(3-(4-(4-fluorophenyl)piperazin-1-yl)-2-(N-m...)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094540(1,3-diphenyl-4,5,6,7-tetrahydro-2H-isoindole | CHE...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50318884(CHEMBL1084546 | CHEMBL2430359 | N-methyl-N-(3-((2-...)
Affinity DataIC50:  1.5nMAssay Description:Reversible inhibition of NH2-terminal 6His-tagged FAK catalytic domain (410 to 689 residues) (unknown origin) expressed in Sf9 insect cells using p(G...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094546(3,5-Diphenyl-4-aza-tricyclo[5.2.2.0*2,6*]undeca-2,...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094534(1,3-Bis-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094532(1,3-Diphenyl-4,5,6,7-tetrahydro-isoindol-2-ylamine...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM10112((3Z)-5-fluoro-3-[(3-methoxy-1H-pyrrol-2-yl)methyli...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094558(3,5-Diphenyl-4-aza-tricyclo[5.2.1.0*2,6*]deca-2,5-...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094548(1,3-Bis-(4-fluoro-phenyl)-2,4,5,6-tetrahydro-cyclo...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM10109((3Z)-4-[(3R,4S,5R)-4-amino-3,5-dihydroxyhex-1-yn-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094528(5,6-Dimethyl-1,3-diphenyl-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094535(1,3-diphenyl-4,7-dihydro-2H-isoindole | CHEMBL1408...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094561(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50:  4.51nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Dr Hs Gour University

Curated by ChEMBL
LigandPNGBDBM50094541(1,3-Bis-(4-chloro-phenyl)-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50:  5nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50132450(3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Syk expressed in Kluyveromyces lactis using Biot-(BA)3-DEEYEIP-NH2 as substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50132450(3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)
Affinity DataIC50:  5nMAssay Description:Inhibition of spleen tyrosine kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50207475(1-(4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl)-3-m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50404086(CHEMBL341226)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50126702(CHEMBL282807 | Isoquinoline-5-sulfonic acid 4-{(S)...)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50126713(CHEMBL282173 | Isoquinoline-5-sulfonic acid 4-{(S)...)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50451951(CHEMBL4217941)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of rat brain AChE using acetylthiocholine iodide as substrate by spectroscopic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM8826(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50451934(CHEMBL4207594)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of rat brain AChE using acetylthiocholine iodide as substrate by spectroscopic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50451935(CHEMBL4208825)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of rat brain AChE using acetylthiocholine iodide as substrate by spectroscopic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50451931(CHEMBL4213552)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of rat brain AChE using acetylthiocholine iodide as substrate by spectroscopic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50258204(2-(4-tert-butylphenyl)-4-(4-((5-ethyl-1-methyl-1H-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50366929(CHEMBL1794057)
Affinity DataIC50:  7nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50451962(CHEMBL4214058)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of rat brain AChE using acetylthiocholine iodide as substrate by spectroscopic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50404085(CHEMBL336619)
Affinity DataIC50:  7.90nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613675(CHEMBL5275659)
Affinity DataIC50:  8nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50126413(CHEMBL287478 | N*1*-[7-(4-Morpholin-4-yl-phenyl)-[...)
Affinity DataIC50:  8nMAssay Description:Inhibition of spleen tyrosine kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50451932(CHEMBL4204793)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of rat brain AChE using acetylthiocholine iodide as substrate by spectroscopic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  9nMAssay Description:Inhibition of cRAF1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM8813(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Affinity DataIC50:  9nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50324735((5E)-5-(QUINOXALIN-6-YLMETHYLENE)-1,3-THIAZOLIDINE...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant GST-tagged PI3Kgamma incubated for 180 mins using [33P]gamma-ATP by scintillation proximity assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50411888(CHEMBL270421)
Affinity DataIC50:  9.10nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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