Affinity DataIC50: 30nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in baculovirus infected Sf21 insect cells using RHKKAc as ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 520nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 3 nM recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 dele...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human topoisomerase 2alpha using supercoiled pBR322 DNA as substrate incubated for 60 mins by ethidium bromide dye based ag...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant wild-type human topoisomerase 2alpha expressed in Saccharomyces cerevisiae using supercoiled pBR322 DNA as substrate measur...More data for this Ligand-Target Pair
Affinity DataIC50: 2.05E+3nMAssay Description:Inhibitory effect against Escherichia coli Gyrase in Supercoiling assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of 3 nM recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 dele...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electroph...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast DNA after 60 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 4.12E+3nMAssay Description:Inhibition of recombinant human C-terminal FLAG-His tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.34E+3nMAssay Description:Inhibitory effect against Escherichia coli Gyrase in Supercoiling assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 4.88E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electroph...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 5.14E+3nMAssay Description:Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast DNA after 60 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 5.44E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electroph...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNAMore data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.96E+3nMAssay Description:Inhibitory effect against Escherichia coli Gyrase in Supercoiling assayMore data for this Ligand-Target Pair