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Found 215 with Last Name = 'sissi' and Initial = 'c'
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196500(CHEMBL224754 | trimethyl(2-{6,8,17,19-tetraoxo-18-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50285612(CHEMBL4167599)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in baculovirus infected Sf21 insect cells using RHKKAc as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196492(2,9-bis-[2-(2-hydroxy-ethylamino)-ethyl]-anthra[2,...)
Affinity DataIC50:  60nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196500(CHEMBL224754 | trimethyl(2-{6,8,17,19-tetraoxo-18-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196491(2,9-bis-(2-dimethylamino-ethyl)-anthra[2,1,9-def;6...)
Affinity DataIC50:  160nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196493((N,N0-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylene...)
Affinity DataIC50:  200nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196492(2,9-bis-[2-(2-hydroxy-ethylamino)-ethyl]-anthra[2,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50285611(CHEMBL4171407)
Affinity DataIC50:  370nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196499(2,9-Bis-(2-piperidin-1-yl-ethyl)-1,2,3,8,9,10-hexa...)
Affinity DataIC50:  400nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50285615(CHEMBL4160757)
Affinity DataIC50:  410nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50285614(CHEMBL4175475)
Affinity DataIC50:  520nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50285613(CHEMBL4172024)
Affinity DataIC50:  550nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50328678(6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexa...)
Affinity DataIC50:  560nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50285612(CHEMBL4167599)
Affinity DataIC50:  560nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196491(2,9-bis-(2-dimethylamino-ethyl)-anthra[2,1,9-def;6...)
Affinity DataIC50:  900nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50261767(CHEMBL4061116)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of 3 nM recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 dele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196501(2,7-bis-(2-dimethylamino-ethyl)-benzo[lmn][3,8]phe...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50501616(CHEMBL4084089)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50493837(CHEMBL2443298)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50554356(CHEMBL4758733)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant human topoisomerase 2alpha using supercoiled pBR322 DNA as substrate incubated for 60 mins by ethidium bromide dye based ag...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50493837(CHEMBL2443298)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50554356(CHEMBL4758733)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant wild-type human topoisomerase 2alpha expressed in Saccharomyces cerevisiae using supercoiled pBR322 DNA as substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Universit£

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibitory effect against Escherichia coli Gyrase in Supercoiling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50501615(CHEMBL4091846)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50261761(CHEMBL4096982)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of 3 nM recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 dele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196498(CHEMBL275860 | NDI-1 | trimethyl(3-{5,7,12,14-tetr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196495(CHEMBL225507 | trimethyl(2-{5,7,12,14-tetraoxo-13-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM22984((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM22984((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast DNA after 60 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50493846(CHEMBL2443290)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50493838(CHEMBL2443297)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50493835(CHEMBL2443288)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196503(2,7-Bis-(3-dimethylamino-propyl)-benzo[lmn][3,8]ph...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of telomerase in JR8 cell extract by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50554356(CHEMBL4758733)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50285612(CHEMBL4167599)
Affinity DataIC50:  4.12E+3nMAssay Description:Inhibition of recombinant human C-terminal FLAG-His tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Universit£

Curated by ChEMBL
LigandPNGBDBM50470984(CHEMBL429961)
Affinity DataIC50:  4.34E+3nMAssay Description:Inhibitory effect against Escherichia coli Gyrase in Supercoiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50240132(CHEMBL4090898)
Affinity DataIC50:  4.88E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196493((N,N0-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylene...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50246439(CHEMBL4082686)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196498(CHEMBL275860 | NDI-1 | trimethyl(3-{5,7,12,14-tetr...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196495(CHEMBL225507 | trimethyl(2-{5,7,12,14-tetraoxo-13-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50208207(CHEMBL3883611)
Affinity DataIC50:  5.14E+3nMAssay Description:Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast DNA after 60 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50240135(CHEMBL4066762)
Affinity DataIC50:  5.44E+3nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50501619(CHEMBL4084827)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196496(2,7-bis-[2-(2-hydroxy-ethylamino)-ethyl]-benzo[lmn...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50501614(CHEMBL583073)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Cagliari

Curated by ChEMBL
LigandPNGBDBM50358566(UNGEREMINE)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50196503(2,7-Bis-(3-dimethylamino-propyl)-benzo[lmn][3,8]ph...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of Taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Universit£

Curated by ChEMBL
LigandPNGBDBM50470990(CHEMBL136779)
Affinity DataIC50:  6.96E+3nMAssay Description:Inhibitory effect against Escherichia coli Gyrase in Supercoiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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