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Found 994 with Last Name = 'spampinato' and Initial = 's'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50095155((S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50095155((S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards Opioid receptor mu 1 by displacing [3H]DAMGO in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University of Bologna

Curated by PDSP Ki Database
LigandPNGBDBM82559(methoctramine analog 5)
Affinity DataKi:  0.290nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University of Bologna

Curated by PDSP Ki Database
LigandPNGBDBM82423(CAS_132947 | NSC_132947 | TRIPITRAMINE)
Affinity DataKi:  0.300nMAssay Description:Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50095154((S)-2-[(S)-2-(2-{1-[(R)-2-Amino-3-((S)-4-hydroxy-p...)
Affinity DataKi:  0.330nMAssay Description:Concentration required for inhibition of [3H]DAMGO binding to Opioid receptor mu 1 in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50340648(CHEMBL4177061)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University of Bologna

Curated by PDSP Ki Database
LigandPNGBDBM50408535(CHEMBL131865)
Affinity DataKi:  0.370nMAssay Description:Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University of Bologna

Curated by PDSP Ki Database
LigandPNGBDBM50408530(CHEMBL1202003)
Affinity DataKi:  0.440nMAssay Description:Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50408535(CHEMBL131865)
Affinity DataKi:  0.5nMAssay Description:Binding affinity for rat cortex Muscarinic acetylcholine receptor M1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  0.5nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University of Bologna

Curated by PDSP Ki Database
LigandPNGBDBM50408527(CHEMBL1202004)
Affinity DataKi:  0.560nMAssay Description:Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50063800(3-(2-Piperidin-1-yl-ethyl)-6-propyl-3H-benzothiazo...)
Affinity DataKi:  0.600nMAssay Description:The compound was tested for the affinity on sigma 1 receptor using [3H]- pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064171(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Affinity DataKi:  0.620nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University of Bologna

Curated by PDSP Ki Database
LigandPNGBDBM50408525(CHEMBL1202000)
Affinity DataKi:  0.910nMAssay Description:Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50408530(CHEMBL1202003)
Affinity DataKi:  0.950nMAssay Description:Binding affinity for rat cortex Muscarinic acetylcholine receptor M1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  1.05nMAssay Description:Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50036764(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Affinity DataKi:  1.40nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50408535(CHEMBL131865)
Affinity DataKi:  1.40nMAssay Description:Inhibition of NG 108-15 binding to Muscarinic acetylcholine receptor M4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membranes after 2 hrs by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards Opioid receptor mu 1 by displacing [3H]DAMGO in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50111628(6-{4-[4-(3,4-Dichloro-benzyl)-piperazin-1-yl]-buty...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for Sigma opioid receptor by displacement of [3H]-DTGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50111626(3-Methyl-6-[2-(4-phenyl-piperidin-1-yl)-ethyl]-3H-...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for Sigma opioid receptor by displacement of [3H]DTGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50111625(6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-ketanserin from rat cortex 5-HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50095151((S)-2-[(S)-2-(2-{1-[(S)-2-Amino-3-((S)-4-hydroxy-p...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards Opioid receptor mu 1 by displacing [3H]DAMGO in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University of Bologna

Curated by PDSP Ki Database
LigandPNGBDBM50408539(CHEMBL407678)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50408527(CHEMBL1202004)
Affinity DataKi:  2.80nMAssay Description:Inhibition of NG 108-15 binding to Muscarinic acetylcholine receptor M4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in HEK293 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in HEK293 cell membranes after 2 hrs by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  2.93nMAssay Description:Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50111627(6-[2-(4-Benzyl-piperazin-1-yl)-ethyl]-3-methyl-3H-...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for Sigma opioid receptor by displacement of [3H]-DTGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Université

Curated by ChEMBL
LigandPNGBDBM50111631(6-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-3-methyl-3H-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50408535(CHEMBL131865)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]NMS binding to rat submaxillary gland Muscarinic acetylcholine receptor M3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50111632(3-Methyl-6-[4-(4-phenyl-piperidin-1-yl)-butyl]-3H-...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for Sigma opioid receptor by displacement of [3H]-DTGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50533844(CHEMBL4513822)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]diprenorphine from human DOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.20nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]diprenorphine from human DOR expressed in HEK293 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM21008((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]diprenorphine from human DOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM21008((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in HEK293 cell membranes after 2 hrs by liquid scintillation spectrometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM82423(CAS_132947 | NSC_132947 | TRIPITRAMINE)
Affinity DataKi:  3.5nMAssay Description:Binding affinity for rat cortex Muscarinic acetylcholine receptor M1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50497848(CHEMBL3319079)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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