Affinity DataKi: 0.0340nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 0.0500nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Binding affinity to alpha4beta2 nAChR in rat cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Positive allosteric modulation of GABAA alpha3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Positive allosteric modulation of GABAA alpha3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Positive allosteric modulation of GABAA alpha3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Positive allosteric modulation of GABAA alpha1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Positive allosteric modulation of GABAA alpha1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
Affinity DataKi: 1.56nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.89nMAssay Description:Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.27nMAssay Description:Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6.5nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 6.80nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 6.80nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 6.80nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 9.10nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 9.30nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 9.5nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 12.3nMAssay Description:Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 12.4nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 17.2nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 20.9nMAssay Description:Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Positive allosteric modulation of GABAA alpha3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair