Affinity DataKi: 2.50E+4nMAssay Description:Inhibition of human unphosphorylated N-terminal-His6 tagged VEGFR2 catalytic domain using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate after 60 mins by mob...More data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human DPP4 purified from Caco2 cells pre-incubated for 15 mins before Gly-Pro-pNA substrate addition and measured after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of recombinant human renin expressed in FreeStyle 293 expression system using recombinant human angiotensinogen as substrate preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 60 mins followed by 1000 uM of ATP addition m...More data for this Ligand-Target Pair
Affinity DataIC50: 0.680nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 60 mins followed by 1000 uM of ATP addition m...More data for this Ligand-Target Pair
Affinity DataIC50: 0.770nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 60 mins followed by 1000 uM of ATP addition m...More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.960nMAssay Description:Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of (5-(6-(10H-spiro(1-benzofuran-3,30-pyrrolidin)-10-yl)pyridazin-3-yl)-1,2,4-oxadiazol-3-yl)[3H2]methanol from SCD1 in human liver micr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human renin expressed in FreeStyle 293 expression system using recombinant human angiotensinogen as substrate preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 5 mins followed by 2 uM of ATP addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 5 mins followed by 2 uM of ATP addition measu...More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 5 mins followed by 2 uM of ATP addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 5 mins followed by 2 uM of ATP addition measu...More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human renin expressed in FreeStyle 293 expression system using recombinant human angiotensinogen as substrate preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human DPP4 purified from Caco2 cells pre-incubated for 15 mins before Gly-Pro-pNA substrate addition and measured after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 5 mins followed by 2 uM of ATP addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Displacement of (5-(6-(10H-spiro(1-benzofuran-3,30-pyrrolidin)-10-yl)pyridazin-3-yl)-1,2,4-oxadiazol-3-yl)[3H2]methanol from SCD1 in human liver micr...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Displacement of (5-(6-(10H-spiro(1-benzofuran-3,30-pyrrolidin)-10-yl)pyridazin-3-yl)-1,2,4-oxadiazol-3-yl)[3H2]methanol from SCD1 in human liver micr...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human DPP4 purified from Caco2 cells pre-incubated for 15 mins before Gly-Pro-pNA substrate addition and measured after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-stimulated arachidonic acid releaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 5 mins followed by 2 uM of ATP addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human renin expressed in FreeStyle 293 expression system using recombinant human angiotensinogen as substrate preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrate preincubated for 60 mins followed by 1000 uM of ATP addition m...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair