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Found 59 with Last Name = 'taya' and Initial = 's'
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123790(3-{[4-Aminomethyl-2-(1-carboxy-ethyl)-phenylcarbam...)
Affinity DataKi:  1nMAssay Description:Binding affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of [3H]- DCKA (5,7-dichlorokynurenic acid) in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123790(3-{[4-Aminomethyl-2-(1-carboxy-ethyl)-phenylcarbam...)
Affinity DataKi:  11nMAssay Description:Binding affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of [3H]- glycine in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073956(CHEMBL85567 | {5-Aminomethyl-2-[2-((S)-9-chloro-2,...)
Affinity DataIC50:  1nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123792(3-[(4-Aminomethyl-2-carboxymethyl-phenylcarbamoyl)...)
Affinity DataIC50:  1.5nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123790(3-{[4-Aminomethyl-2-(1-carboxy-ethyl)-phenylcarbam...)
Affinity DataIC50:  2.70nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123796(3-[(2-Carboxymethyl-phenylcarbamoyl)-methyl]-7-chl...)
Affinity DataIC50:  7.60nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123791(3-[(4-Aminomethyl-phenylcarbamoyl)-methyl]-7-chlor...)
Affinity DataIC50:  18nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123795(7-Chloro-3-phenylcarbamoylmethyl-1,3,4,5-tetrahydr...)
Affinity DataIC50:  19nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197913((3R)-N-[1-(3-aminobenzyl)-3-pyrrolidyl]-N-(5-isoqu...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123794(3-{[4-Aminomethyl-2-(1-carboxy-ethyl)-phenylcarbam...)
Affinity DataIC50:  29nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123793(3-[(4-Aminomethyl-2-carboxymethoxy-phenylcarbamoyl...)
Affinity DataIC50:  33nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123793(3-[(4-Aminomethyl-2-carboxymethoxy-phenylcarbamoyl...)
Affinity DataIC50:  33nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197914(CHEMBL375556 | N-(1-(4-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197915(CHEMBL223815 | N-(1-(3-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197922(CHEMBL224361 | N1-cyclopropyl-N4-(5-isoquinolyl)-1...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197907(CHEMBL387954 | N-(1-(2,6-difluorobenzyl)pyrrolidin...)
Affinity DataIC50:  75nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human VEGFR2 kinase domain expressed in SF9 cells by TR-FRET assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197900(CHEMBL223336 | N-(1-(4-fluorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  95nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197901(CHEMBL389926 | N-(1-(2-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197919(CHEMBL224505 | N-(1-benzyl-4-piperidyl)-N-(5-isoqu...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197920(CHEMBL266512 | N1-propyl-N4-(5-isoquinolyl)-1,4-cy...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197911(CHEMBL224360 | N1-propyl-N4-(5-isoquinolyl)-1,4-cy...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197902(CHEMBL225492 | N-(1-(4-chlorobenzyl)piperidin-3-yl...)
Affinity DataIC50:  185nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197921(CHEMBL375735 | N1-cyclopropyl-N4-(5-isoquinolyl)-1...)
Affinity DataIC50:  195nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197904(CHEMBL388285 | N-(1-(2-aminobenzyl)pyrrolidin-3-yl...)
Affinity DataIC50:  205nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197906(CHEMBL224508 | N-(1-(2-chlorobenzyl)piperidin-3-yl...)
Affinity DataIC50:  210nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197908(CHEMBL375882 | N-(1-isobutyl-4-piperidyl)-N-(5-iso...)
Affinity DataIC50:  210nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197903(CHEMBL223907 | N-(1-(4-aminobenzyl)pyrrolidin-3-yl...)
Affinity DataIC50:  235nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197909(CHEMBL389254 | N-(1-(3-chlorobenzyl)piperidin-3-yl...)
Affinity DataIC50:  265nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197905(CHEMBL375736 | N-(1-isopentyl-3-pyrrolidyl)-N-(5-i...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197910(CHEMBL373759 | N-(1-(3-aminobenzyl)pyrrolidin-3-yl...)
Affinity DataIC50:  275nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197912((3S)-N-[1-(3-aminobenzyl)-3-pyrrolidyl]-N-(5-isoqu...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197918(CHEMBL224472 | N-(1-ethylpiperidin-4-yl)isoquinoli...)
Affinity DataIC50:  345nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197917(CHEMBL224362 | N1-phenylethyl-N4-(5-isoquinolyl)-1...)
Affinity DataIC50:  440nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL
LigandPNGBDBM50491277(CHEMBL2381858)
Affinity DataIC50:  560nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in insect cells using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 to 60 mins by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197916(CHEMBL224417 | N1-phenylethyl-N4-(5-isoquinolyl)-1...)
Affinity DataIC50:  580nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197913((3R)-N-[1-(3-aminobenzyl)-3-pyrrolidyl]-N-(5-isoqu...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197907(CHEMBL387954 | N-(1-(2,6-difluorobenzyl)pyrrolidin...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197914(CHEMBL375556 | N-(1-(4-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197915(CHEMBL223815 | N-(1-(3-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197904(CHEMBL388285 | N-(1-(2-aminobenzyl)pyrrolidin-3-yl...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197903(CHEMBL223907 | N-(1-(4-aminobenzyl)pyrrolidin-3-yl...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Kyoto University

LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataIC50:  1.51E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence intensity was measured at 420 nm excitation and 485 nm emission using a microplate reader (MPR-A4ιII; TOSOH, Tokyo, Japan, or Fluoroska...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Kyoto University

LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  1.53E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence intensity was measured at 420 nm excitation and 485 nm emission using a microplate reader (MPR-A4ιII; TOSOH, Tokyo, Japan, or Fluoroska...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197901(CHEMBL389926 | N-(1-(2-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197910(CHEMBL373759 | N-(1-(3-aminobenzyl)pyrrolidin-3-yl...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197900(CHEMBL223336 | N-(1-(4-fluorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50197902(CHEMBL225492 | N-(1-(4-chlorobenzyl)piperidin-3-yl...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Kyoto University

LigandPNGBDBM212434((2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl...)
Affinity DataIC50:  2.53E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence intensity was measured at 420 nm excitation and 485 nm emission using a microplate reader (MPR-A4ιII; TOSOH, Tokyo, Japan, or Fluoroska...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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