Affinity DataKi: 400nMAssay Description:Displacement of 125I-MCP1 from human CCR2 receptor expressed in human HEK cell membraneMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataKi: 423nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataKi: 1.17E+3nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.600nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.80nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK1 (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 2.58nMAssay Description:ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...More data for this Ligand-Target Pair
Affinity DataIC50: 2.76nMAssay Description:ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: 3nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Displacement of 125I-MCP1 from human CCR2 receptor expressed in human THP-1 cell membrane by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.75nMpH: 7.4 T: 2°CAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of 125I-MCP1 from human CCR2 receptor expressed in human THP-1 cell membrane by SPA assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 5nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibition of MCP1-induced CCR2-mediated chemotaxis in human THP-1 cellsMore data for this Ligand-Target Pair