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Found 1609 with Last Name = 'warmus' and Initial = 'js'
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50200120(CHEMBL260091 | CHIR-090 | US10875832, Compound ChI...)
Affinity DataKi:  2nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50478376(BB-78485 | CHEMBL261713)
Affinity DataKi:  20nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255538((4-(4-(3-chlorobenzyloxy)-3-methylbenzoyl)piperazi...)
Affinity DataKi:  23.9nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255483(4-(3-chloro-4-(3-chlorobenzyloxy)benzoyl)-1-methyl...)
Affinity DataKi:  37.2nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50074960((R)-2-(3,4-Dimethoxy-5-propyl-phenyl)-4,5-dihydro-...)
Affinity DataKi:  50nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
TargetHigh affinity choline transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071542((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-5-[2-(...)
Affinity DataKi:  82nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255662(3-chloro-4-(3-chlorobenzyloxy)-N-(4-hydroxybutyl)b...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255768(2-(4-chloro-5-(3-chlorobenzyloxy)pyridin-2-yl)-1,3...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071543((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-4-oxo-...)
Affinity DataKi:  113nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133601(CHEMBL3633251)
Affinity DataKi:  151nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133602(CHEMBL3633250)
Affinity DataKi:  174nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi:  250nMAssay Description:Inhibition of human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)
Affinity DataKi:  316nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133596(CHEMBL3633459)
Affinity DataKi:  347nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133603(CHEMBL3633248)
Affinity DataKi:  372nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133600(CHEMBL3633457)
Affinity DataKi:  501nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483375(CHEMBL1236446)
Affinity DataKi:  650nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]Dofetilide from recombinant human ERG after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi:  1.35E+3nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  2.12E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275437(CHEMBL4129620)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 min by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM200318(US9227956, 3)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071541((S)-3-(benzyloxycarbonylamino)-4-oxo-5-(3-phenylpr...)
Affinity DataKi:  4.50E+3nMAssay Description:Compound was tested for binding affinity against N-His (D381E) Interleukin -1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275430(CHEMBL4130157)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM200324(US9227956, 9)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi:  7.73E+3nMAssay Description:Inhibition of human MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-26(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP26More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-25(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-24(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP24More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-20(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP20More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP16More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275486(CHEMBL4128560)
Affinity DataKi:  1.27E+4nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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