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Found 754 with Last Name = 'westphal' and Initial = 'm'
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419188(5-[Difluoro(phenyl)methyl]-7-(1,2,5-triazaspiro[2....)
Affinity DataKi:  0.800nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419309(2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)tr...)
Affinity DataKi:  1nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419190(5-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-(1,2,5-t...)
Affinity DataKi:  3.30nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419260(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({2...)
Affinity DataKi:  4.20nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419306(3-[2-[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1...)
Affinity DataKi:  5nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419261(5-tert-Butyl-3-[(2-ethynylphenyl)methyl]-7-(1,2,5-...)
Affinity DataKi:  5.60nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419300(2-[2-[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1...)
Affinity DataKi:  6nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419278(2-{[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3...)
Affinity DataKi:  6nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419269(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2...)
Affinity DataKi:  9nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419296(2-[[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-y...)
Affinity DataKi:  9nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419262(3-[(2-Chlorophenyl)methyl]-5-[difluoro(phenyl)meth...)
Affinity DataKi:  9.90nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419273((2-{[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-...)
Affinity DataKi:  11nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419270((3S)-1-[5-tert-Butyl-3-[[2-ethynyl-6-[3-(trifluoro...)
Affinity DataKi:  12nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419272(2-[[5-tert-Butyl-7-[(3S)-3-hydroxypyrrolidin-1-yl]...)
Affinity DataKi:  16nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419185(5-tert-Butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)met...)
Affinity DataKi:  16.1nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419267(5-[Difluoro(phenyl)methyl]-3-[(2-ethynylphenyl)met...)
Affinity DataKi:  19nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419302(2-[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl...)
Affinity DataKi:  27nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419268(5-[Difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolid...)
Affinity DataKi:  31nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419263(5-[Difluoro(phenyl)methyl]-3-[(4-methyl-1,2,5-oxad...)
Affinity DataKi:  45.5nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419264(5-tert-Butyl-3-({2-chloro-4-[3-(trifluoromethyl)-3...)
Affinity DataKi:  55.6nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419271((3S)-1-[5-[Difluoro(phenyl)methyl]-3-[[2-ethynyl-6...)
Affinity DataKi:  58nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419304(2-[2-[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1...)
Affinity DataKi:  63nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419303(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2...)
Affinity DataKi:  72nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419314(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-[[2...)
Affinity DataKi:  81.4nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419279(1-{5-tert-Butyl-3-[(2-chlorophenyl)methyl]-3H-[1,2...)
Affinity DataKi:  85nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419275(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-{[2...)
Affinity DataKi:  88nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419276((3S)-1-(5-tert-Butyl-3-{[2-(isothiocyanatomethyl)p...)
Affinity DataKi:  91nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419307(2-[[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-y...)
Affinity DataKi:  95nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419315((3S)-1-[5-tert-Butyl-2-[[2-ethynyl-6-[3-(trifluoro...)
Affinity DataKi:  99.2nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419261(5-tert-Butyl-3-[(2-ethynylphenyl)methyl]-7-(1,2,5-...)
Affinity DataKi:  132nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419306(3-[2-[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1...)
Affinity DataKi:  135nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419285(7-(3-Azidopyrrolidin-1-yl)-5-tert-butyl-3-[(4-meth...)
Affinity DataKi:  137nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419299(2-[2-[2-[[5-[Difluoro(phenyl)methyl]-7-(3,3-difluo...)
Affinity DataKi:  138nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419269(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2...)
Affinity DataKi:  147nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419281((3S)-1-{5-tert-Butyl-3-[(4-methyl-1,2,5-oxadiazol-...)
Affinity DataKi:  153nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419305(2-[2-[2-[[5-[Difluoro(phenyl)methyl]-7-(3,3-difluo...)
Affinity DataKi:  177nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419266(4-({5-tert-Butyl-7-[(3S)-3-hydroxypyrrolidin-1-yl]...)
Affinity DataKi:  200nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419300(2-[2-[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1...)
Affinity DataKi:  205nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419288(7-(3-Azidopyrrolidin-1-yl)-5-tert-butyl-3-[(2-chlo...)
Affinity DataKi:  210nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419118(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-{[2...)
Affinity DataKi:  211nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419296(2-[[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-y...)
Affinity DataKi:  211nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419305(2-[2-[2-[[5-[Difluoro(phenyl)methyl]-7-(3,3-difluo...)
Affinity DataKi:  230nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419301(3-[[2-[2-(Benzotriazol-1-ylsulfonyl)ethyl]phenyl]m...)
Affinity DataKi:  246nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419298(5-[Difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolid...)
Affinity DataKi:  262nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419274(US10457685, Example 3 | [2-({5-tert-Butyl-7-[(3S)-...)
Affinity DataKi:  283nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419277(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[(2...)
Affinity DataKi:  300nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419309(2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)tr...)
Affinity DataKi:  311nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419190(5-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-(1,2,5-t...)
Affinity DataKi:  321nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419316((3S)-1-[5-[Difluoro(phenyl)methyl]-2-[[2-ethynyl-6...)
Affinity DataKi:  358nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419117(2-{[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-2...)
Affinity DataKi:  361nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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