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Found 203 with Last Name = 'whipple' and Initial = 'da'
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286335((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-(3-...)
Affinity DataKi:  1nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286344(5-[(S)-2-((R)-2-Hydroxycarbamoylmethyl-4-methyl-pe...)
Affinity DataKi:  1nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286340((R)-N*1*-[(S)-1-(4-Benzyloxy-butylcarbamoyl)-2-(1H...)
Affinity DataKi:  2nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataKi:  2nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286337((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-(2-...)
Affinity DataKi:  2nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286334((R)-N*4*-Hydroxy-N*1*-{(S)-2-(1H-indol-3-yl)-1-[5-...)
Affinity DataKi:  2nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286350((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-(2-...)
Affinity DataKi:  3nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286339((R)-N*1*-[(S)-1-(2-Ethylsulfanyl-ethylcarbamoyl)-2...)
Affinity DataKi:  3nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286349((R)-N*1*-[(S)-1-(3-Dimethylamino-propylcarbamoyl)-...)
Affinity DataKi:  3nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286347((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-(2-...)
Affinity DataKi:  3nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286345((R)-N*1*-[(S)-1-(4-Dimethylamino-butylcarbamoyl)-2...)
Affinity DataKi:  3nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286343((R)-N*1*-[(S)-1-(4-Dimethylaminomethyl-benzylcarba...)
Affinity DataKi:  4nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286346((R)-N*4*-Hydroxy-N*1*-{(S)-2-(1H-indol-3-yl)-1-[2-...)
Affinity DataKi:  4nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286336((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-(2-...)
Affinity DataKi:  5nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286348((R)-N*1*-[(S)-1-[2-(2-Dimethylamino-ethylsulfanyl)...)
Affinity DataKi:  5nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286342((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-(2-...)
Affinity DataKi:  5nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi:  6nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286338((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-(2-...)
Affinity DataKi:  6nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286341((R)-N*1*-[(S)-1-(2-Dimethylamino-ethylcarbamoyl)-2...)
Affinity DataKi:  12nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataKi:  37nMAssay Description:Displacement of radio-labeled U69,593 from rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataKi:  50nMAssay Description:Displacement of radio-labeled U69,593 from rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataKi:  53nMAssay Description:Displacement of radio-labeled U69,593 from rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataKi:  73nMAssay Description:Displacement of radio-labeled U69,593 from rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataKi:  306nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataKi:  1.09E+3nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataKi:  1.75E+3nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataKi:  2.33E+3nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataKi:  5.19E+3nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataKi:  8.17E+3nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of JAK2 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332622(CHEMBL1630782 | N-Methyl-N-((1S,2R,5S)-2-methyl-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097704(CHEMBL3590200)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of JAK3 by solution phase kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097700(CHEMBL3590196)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097701(CHEMBL3590197)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332622(CHEMBL1630782 | N-Methyl-N-((1S,2R,5S)-2-methyl-5-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of JAK1 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataIC50:  5.30nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097696(CHEMBL3590192)
Affinity DataIC50:  10nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332620(2-Methyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332623(CHEMBL1630786 | N-Benzyl-2-((R)-2-((1S,3S,4R)-4-me...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332604(CHEMBL1630788 | cis-N-Methyl-N-(4-methyl-1-(2,2,2-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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