Compile Data Set for Download or QSAR
maximum 50k data
Found 33 with Last Name = 'wickson' and Initial = 'kf'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35948(4-pyridinoxy-2-anilinopyridine-based compound, 12)
Affinity DataIC50:  4nM EC50:  32nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35949(4-pyridinoxy-2-anilinopyridine-based compound, 13)
Affinity DataIC50:  6nM EC50:  62nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35946(4-pyridinoxy-2-anilinopyridine-based compound, 10)
Affinity DataIC50:  7nM EC50:  114nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35953(4-pyridinoxy-2-anilinopyridine-based compound, 17)
Affinity DataIC50:  12nM EC50:  31nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35941(4-pyridinoxy-2-anilinopyridine-based compound, 5)
Affinity DataIC50:  13nM EC50:  20nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35952(4-pyridinoxy-2-anilinopyridine-based compound, 16)
Affinity DataIC50:  21nM EC50:  27nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35950(4-pyridinoxy-2-anilinopyridine-based compound, 14)
Affinity DataIC50:  30nM EC50:  35nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35942(4-pyridinoxy-2-anilinopyridine-based compound, 6)
Affinity DataIC50:  35nM EC50:  21nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35939(4-pyridinoxy-2-anilinopyridine-based compound, 1)
Affinity DataIC50:  44nM EC50:  55nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35955(4-pyridinoxy-2-anilinopyridine-based compound, 19)
Affinity DataIC50:  72nM EC50:  22nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35945(4-pyridinoxy-2-anilinopyridine-based compound, 9)
Affinity DataIC50:  107nM EC50:  628nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35944(4-pyridinoxy-2-anilinopyridine-based compound, 8)
Affinity DataIC50:  108nM EC50:  282nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35951(4-pyridinoxy-2-anilinopyridine-based compound, 15)
Affinity DataIC50:  109nM EC50:  146nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35954(4-pyridinoxy-2-anilinopyridine-based compound, 18)
Affinity DataIC50:  129nM EC50:  63nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35943(4-pyridinoxy-2-anilinopyridine-based compound, 7)
Affinity DataIC50:  227nM EC50: >5.80E+3nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35947(4-pyridinoxy-2-anilinopyridine-based compound, 11)
Affinity DataIC50:  739nM EC50: >3.00E+3nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50615236(CHEMBL5267198)
Affinity DataKd:  470nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615235(CHEMBL5269798)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615234(CHEMBL5282328)
Affinity DataKd:  340nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
LigandPNGBDBM50615233(CHEMBL5280275)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615232(CHEMBL5280696)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50508948(CHEMBL4473598)
Affinity DataKd:  20nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50508950(CHEMBL4472439)
Affinity DataKd:  120nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50508940(CHEMBL4582512)
Affinity DataKd:  3.54E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615231(CHEMBL5266160)
Affinity DataKd:  530nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615230(CHEMBL5268588)
Affinity DataKd:  290nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50508947(CHEMBL4460550)
Affinity DataKd:  370nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50508936(CHEMBL4590345)
Affinity DataKd:  4.48E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615229(CHEMBL5282122)
Affinity DataKd:  100nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
LigandPNGBDBM50615228(CHEMBL5277654)
Affinity DataKd:  420nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615227(CHEMBL5288551)
Affinity DataKd:  720nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615237(CHEMBL5275336)
Affinity DataKd:  290nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615226(CHEMBL5269652)
Affinity DataKd:  770nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed