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Found 371 with Last Name = 'wold' and Initial = 'ea'
TargetD(2) dopamine receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.120nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559185(CHEMBL4743313)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain homogenate incubated for 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559179(CHEMBL4792161)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin-Hartley guinea pig brain membranes incubated for 180 mins by liquid scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260083(CHEMBL4104956)
Affinity DataKi:  0.600nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260067(CHEMBL4078267 | US9957263, Example 78)
Affinity DataKi:  0.600nMAssay Description:Inhibition of recombinant human His6-tagged BRD4 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells preincubated for 30 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260067(CHEMBL4078267 | US9957263, Example 78)
Affinity DataKi:  0.900nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559180(CHEMBL4749734)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin guinea pig brain membranes incubated for 120 mins by scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260084(CHEMBL4096313 | US9957263, Example 110)
Affinity DataKi:  1.10nMAssay Description:Inhibition of BRD4 in human HepG2 cells assessed as upregulation of ApoA1 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260065(CHEMBL4088597 | US9957263, Example 63)
Affinity DataKi:  1.30nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated histone H4 as substrate after 1 hr by Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260065(CHEMBL4088597 | US9957263, Example 63)
Affinity DataKi:  1.30nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559173(CHEMBL4796613)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559184(CHEMBL4763051)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559183(CHEMBL4796879)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559182(CHEMBL4744344)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260083(CHEMBL4104956)
Affinity DataKi:  1.60nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260066(CHEMBL4067346 | US9957263, Example 4)
Affinity DataKi:  1.70nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 2 (E352 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559174(CHEMBL4782131)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260068(CHEMBL4075943 | US9957263, Example 39)
Affinity DataKi:  2.10nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (67 to 152 residues) (unknown origin) using acetyl-histone H4 as substrate after overnight incubation by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260084(CHEMBL4096313 | US9957263, Example 110)
Affinity DataKi:  2.20nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 2 (E352 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50001028((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559177(CHEMBL4760592)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Soochow University

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of radioligand binding to sigma1 receptor in C57BL/6 mouse brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559181(CHEMBL4760729)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50001028((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260068(CHEMBL4075943 | US9957263, Example 39)
Affinity DataKi:  4.60nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50503346(CHEMBL4560254)
Affinity DataKi:  6.40nMAssay Description:Positive allosteric modulation of 5-HT2C receptor (unknown origin) assessed as increase in 5-HT-induced displacement of [3H]mesulergine by measuring ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559176(CHEMBL4745051)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559170(CHEMBL4777306)
Affinity DataKi:  8nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559175(CHEMBL4759075)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260066(CHEMBL4067346 | US9957263, Example 4)
Affinity DataKi:  11nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50001028((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Affinity DataKi:  12nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  15nMAssay Description:Agonist activity at 5-HT2CR (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM342597(N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindo...)
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human His6-tagged BRD2 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataKi:  15nMAssay Description:Inhibition of [3H]DTG binding to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559172(J2.179.155E | T-817 maleate | T-817ma)
Affinity DataKi:  16nMAssay Description:Inhibition of (+)-pentazocine binding to human sigma 1 receptor expressed in human Jurkat cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559179(CHEMBL4792161)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-methylhistamine from Histamine H3 receptor in rat cerebral cortex incubated for 30 min by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50028091((1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260082(CHEMBL4075159)
Affinity DataKi:  38nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 2 (E352 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559178(CHEMBL4763854)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation countin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM342597(N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindo...)
Affinity DataKi:  43nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 2 (E352 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM94507(2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopenta...)
Affinity DataKi:  76nMAssay Description:Binding affinity to muscarinic acetylcholine receptor M1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50308028(4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine | ...)
Affinity DataKi:  82nMAssay Description:Inhibition of [3H](+)-pentazocine binding to human sigma1 receptor expressed in HEK293 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))TBA
LigandPNGBDBM50188594(CHEBI:62878 | CHEMBL1086580)
Affinity DataKi:  100nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50188594(CHEBI:62878 | CHEMBL1086580)
Affinity DataKi:  100nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  112nMAssay Description:Agonist activity at 5-HT2AR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559177(CHEMBL4760592)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes incubated for 120 mins by solid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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