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Found 1304 with Last Name = 'wos' and Initial = 'ja'
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189013((S)-2-[(S)-4-{(R)-2-[(S)-2-acetylamino-3-(3H-imida...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human MC1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189024((S)-2-[(S)-4-[(R)-2-[(S)-2-acetylamino-3-(4-hydrox...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189010((S)-2-[(S)-4-{(R)-2-[(S)-2-acetylamino-3-(4-hydrox...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191554((S)-2-acetamido-N-((R)-1-((2S,4R)-2-(3-guanidinopr...)
Affinity DataKi:  0.650nMAssay Description:Displacement of europium labeled NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189013((S)-2-[(S)-4-{(R)-2-[(S)-2-acetylamino-3-(3H-imida...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189010((S)-2-[(S)-4-{(R)-2-[(S)-2-acetylamino-3-(4-hydrox...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189010((S)-2-[(S)-4-{(R)-2-[(S)-2-acetylamino-3-(4-hydrox...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human MC1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189013((S)-2-[(S)-4-{(R)-2-[(S)-2-acetylamino-3-(3H-imida...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189025((S)-2-acetamido-N1-((R)-3-(4-fluorophenyl)-1-((S)-...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189024((S)-2-[(S)-4-[(R)-2-[(S)-2-acetylamino-3-(4-hydrox...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191569((S)-2-Acetamido-N-((R)-1-((2S,4S)-2-(3-guanidinopr...)
Affinity DataKi:  1.30nMAssay Description:Displacement of europium labeled NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189023((S)-2-((S)-4-((R)-3-(4-fluorophenyl)-2-(piperazin-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189014((S)-2-((S)-4-((R)-2-acetamido-3-(4-fluorophenyl)pr...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253660(2-{3-(2-Amino-ethyl-guanidino)-4-[2-amino-3-(4-flu...)
Affinity DataKi:  1.40nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189025((S)-2-acetamido-N1-((R)-3-(4-fluorophenyl)-1-((S)-...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human MC1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189022((S)-2-[(S)-4-[(R)-2-[(S)-2-acetylamino-3-(3H-imida...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human MC1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198573((S)-1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  3nMAssay Description:Binding affinity at MCHR1 by flash plate radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189025((S)-2-acetamido-N1-((R)-3-(4-fluorophenyl)-1-((S)-...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198574((S)-4-(4-chlorophenethyl)-1-(6-((diethylamino)-met...)
Affinity DataKi:  3.30nMAssay Description:Functional antagonism of MCH-R1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198574((S)-4-(4-chlorophenethyl)-1-(6-((diethylamino)-met...)
Affinity DataKi:  4nMAssay Description:Binding affinity at MCHR1 by flash plate radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50203064((S)-4-(4-bromophenethyl)-1-(6-((diethylamino)-meth...)
Affinity DataKi:  4nMAssay Description:Binding affinity at MCHR1 by flash plate radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253738(CHEMBL449131 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
Affinity DataKi:  4nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253736(CHEMBL506272 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
Affinity DataKi:  4nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189023((S)-2-((S)-4-((R)-3-(4-fluorophenyl)-2-(piperazin-...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to human MC1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191575((S)-2-acetamido-N-((R)-1-((2R,4R)-2-(3-guanidinopr...)
Affinity DataKi:  4.70nMAssay Description:Displacement of europium labeled NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253748((2S)-N-((1R)-1-[(4-Fluorophenyl)methyl]-2-{(2S)-4-...)
Affinity DataKi:  5nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189022((S)-2-[(S)-4-[(R)-2-[(S)-2-acetylamino-3-(3H-imida...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253745((S)-2-((S)-4-((R)-3-(4-Fluorophenyl)-2-(2-(methyla...)
Affinity DataKi:  5nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179466((2R,5R)-5-acetylamino-2-(4-fluoro-benzyl)-6-(4-hyd...)
Affinity DataKi:  5nMAssay Description:Binding affinity to MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253749(CHEMBL506762 | N-((1R)-1-[(4-Fluorophenyl)methyl]-...)
Affinity DataKi:  5.20nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189009((S)-2-((S)-4-(3-(4-fluorophenyl)propanoyl)-3-(3-gu...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253750((3S)-N-((1R)-1-[(4-Fluorophenyl)methyl]-2-{(2S)-4-...)
Affinity DataKi:  5.5nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189011((S)-2-((S)-4-((R)-2-amino-3-phenylpropanoyl)-3-(3-...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253739(CHEMBL463047 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
Affinity DataKi:  6nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253746((2S)-N-Methyl-2-[(3S)-4-(N-methyl-L-alanyl-4-fluor...)
Affinity DataKi:  6nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189021(CHEMBL215895 | N-((R)-3-(4-fluorophenyl)-1-((S)-2-...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189019((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Affinity DataKi:  7nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192169((R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrr...)
Affinity DataKi:  7nMAssay Description:Binding activity against human MCH-R1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189014((S)-2-((S)-4-((R)-2-acetamido-3-(4-fluorophenyl)pr...)
Affinity DataKi:  7nMAssay Description:Binding affinity to human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50203054(4'-fluoro-biphenyl-4-carboxylic acid [2-(4-dimethy...)
Affinity DataKi:  7nMAssay Description:Binding affinity at MCHR1 by flash plate radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241095((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Affinity DataKi:  7.40nMAssay Description:Functional antagonism of MCH-R1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253733(2-{4-[2-Acetylamino-3-(4-fluoro-phenyl)-propionyl]...)
Affinity DataKi:  8nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253741((S)-2-((S)-4-((R)-2-Acetamido-3-amino propan-(4-fl...)
Affinity DataKi:  9nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity towards human Melanocortin 4 ReceptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179460((R)-2-acetylamino-N-{(R)-1-benzyl-2-[(2S,4R)-4-ben...)
Affinity DataKi:  9nMAssay Description:Binding affinity to MC1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192189(3,4,5-trifluoro-N-(1-(naphthalen-2-ylmethyl)piperi...)
Affinity DataKi:  9nMAssay Description:Binding activity against human MCH-R1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50203063((S)-4-(3-fluorophenethyl)-1-(6-((diethylamino)-met...)
Affinity DataKi:  10nMAssay Description:Binding affinity at MCHR1 by flash plate radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191556((S)-N-((R)-1-((2S,4R)-2-(3-guanidinopropyl)-4-(nap...)
Affinity DataKi:  10nMAssay Description:Displacement of europium labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179460((R)-2-acetylamino-N-{(R)-1-benzyl-2-[(2S,4R)-4-ben...)
Affinity DataKi:  10nMAssay Description:Binding affinity to MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189008((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Affinity DataKi:  11nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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