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Found 230 with Last Name = 'wyss' and Initial = 'd'
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25771(1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-ph...)
Affinity DataKi:  0.390nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318156(CHEMBL1094785 | carmoterol)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50151720(ARFORMOTEROL TARTRATE | CHEMBL1363 | CHEMBL605993 ...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318159(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-y...)
Affinity DataKi:  76nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318157(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-di-n-butylindan-...)
Affinity DataKi:  112nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318158(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-di-n-propylindan...)
Affinity DataKi:  119nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318161(8-Hydroxy-5-[(R)-1-hydroxy-2-(indan-2-ylamino)-eth...)
Affinity DataKi:  218nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318155(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethoxyindan-2...)
Affinity DataKi:  342nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318160(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethylindan-2-...)
Affinity DataKi:  522nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318154(8-Hydroxy-5-[(R)-1-hydroxy-2-(4,7-diethylindan-2-y...)
Affinity DataKi:  692nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300228((2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)...)
Affinity DataKi:  740nMAssay Description:Inhibition of human cathepsin D preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145828(2-(4-{3-[(S)-1-Carboxy-2-(4-hydroxy-3,5-diiodo-phe...)
Affinity DataKi:  800nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145844(2-(4-{3-[(S)-1-tert-Butoxycarbonyl-2-(4-hydroxy-3,...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25769(4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxym...)
Affinity DataKi:  1.83E+3nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318153((2S,3S,4S,5R,6S)-6-(5-((R)-2-(5,6-diethyl-2,3-dihy...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145820(3-(4-Hydroxy-3,5-diiodo-phenyl)-propionic acid | C...)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145823(3-(4-Hydroxy-3,5-diiodo-phenyl)-3-phenyl-propionic...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145804(3-(4-Hydroxy-3,5-diiodo-phenyl)-2-phenyl-propionic...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145815(4-(4-Hydroxy-3,5-diiodo-phenyl)-butyric acid | CHE...)
Affinity DataKi:  1.80E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145808((R)-2-Acetylamino-3-(4-hydroxy-3,5-diiodo-phenyl)-...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145825((R)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3,5-di...)
Affinity DataKi:  2.60E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145833((S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3,5-di...)
Affinity DataKi:  3.10E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145835(4-Hydroxy-3,5-diiodo-benzoic acid | CHEMBL83650)
Affinity DataKi:  6.00E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145827(CHEMBL311209 | N-[(4-methylbenzene)sulfonamido]ben...)
Affinity DataKi:  6.50E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50604556(CHEMBL5175703)
Affinity DataIC50:  0.200nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509399(CHEMBL4468010)
Affinity DataIC50:  0.300nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318156(CHEMBL1094785 | carmoterol)
Affinity DataIC50:  0.300nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50151720(ARFORMOTEROL TARTRATE | CHEMBL1363 | CHEMBL605993 ...)
Affinity DataIC50:  0.400nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataIC50:  0.700nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318161(8-Hydroxy-5-[(R)-1-hydroxy-2-(indan-2-ylamino)-eth...)
Affinity DataIC50:  0.830nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM573971(US11453697, Example 247)
Affinity DataIC50:  1.10nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509408(CHEMBL4459563)
Affinity DataIC50:  1.30nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM573856(US11453697, Example 20)
Affinity DataIC50:  1.40nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509422(CHEMBL4476079)
Affinity DataIC50:  1.40nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509431(CHEMBL4589856)
Affinity DataIC50:  1.5nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604561(CHEMBL5197904)
Affinity DataIC50:  1.70nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50:  1.80nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50604563(CHEMBL5201164)
Affinity DataIC50:  1.90nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604560(CHEMBL5180005)
Affinity DataIC50:  2nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318155(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethoxyindan-2...)
Affinity DataIC50:  2.30nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50604555(CHEMBL5181746)
Affinity DataIC50:  2.90nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604562(CHEMBL5185127)
Affinity DataIC50:  3.10nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509412(CHEMBL4474321 | US11453697, Example 1)
Affinity DataIC50:  3.5nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25771(1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-ph...)
Affinity DataIC50:  3.5nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50604559(CHEMBL5174023)
Affinity DataIC50:  3.70nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604557(CHEMBL5191008)
Affinity DataIC50:  4.20nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318159(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-y...)
Affinity DataIC50:  7.90nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509430(CHEMBL4570468)
Affinity DataIC50:  8.30nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509425(CHEMBL4566174 | US11453697, Example 27)
Affinity DataIC50:  10nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50066461(CHEMBL326408 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)
Affinity DataIC50:  13nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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