TargetDihydrofolate reductase(Homo sapiens (Human))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataKi: 0nMAssay Description:Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 0.00140nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.00140nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.00140nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.00150nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0130nMAssay Description:Inhibition of human factor 10a using S-2765 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Competitive inhibition of Candida albicans DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of human trypsin using S-2222 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of human thrombin using S-2366 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 800nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.80E+3nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 3.20E+3nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Inhibitory activity of the compound was measured against partially purified pig liver Squalene epoxidase (SE).More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Hefei University Of Technology
Curated by ChEMBL
Hefei University Of Technology
Curated by ChEMBL
Affinity DataKi: 8.30E+3nMAssay Description:Competitive inhibition of recombinant human MAO-B using farnesylamine as substrate by horseradish peroxidase-Amplex red-coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.50E+4nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.02E+5nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.13E+5nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.52E+5nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.90E+5nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0580nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced contraction of rat isolated thoracic aortic stripMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of matrix metalloproteinase-9, gelatinase-BMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of matrix metalloproteinase-9, gelatinase-BMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced contraction of rat isolated thoracic aortic stripMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:In vitro ability to inhibit HMG-CoA reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMAssay Description:In vitro ability to inhibit HMG-CoA reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced contraction of rat isolated thoracic aortic stripMore data for this Ligand-Target Pair
Affinity DataIC50: 0.550nMAssay Description:In vitro ability to inhibit HMG-CoA reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced contraction of rat isolated thoracic aortic stripMore data for this Ligand-Target Pair