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Found 88 with Last Name = 'yang' and Initial = 'eg'
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296480(CHEMBL553249)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296473(CHEMBL558940)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296481(CHEMBL562618)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296477(CHEMBL563460)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296478(CHEMBL557433)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296476(CHEMBL557420)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296479(CHEMBL562806)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296475(CHEMBL557344)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296474(CHEMBL558009)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296482(CHEMBL541769)
Affinity DataKi:  7.70E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296483(CHEMBL538372)
Affinity DataKi:  1.09E+5nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296472(CHEMBL558824)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50333656((2,3-dichlorophenyl)(4-(3-(thiazol-2-ylamino)benzy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM14192(3-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}a...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50333657((4-((6-(1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)p...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210257(CHEMBL3961053)
Affinity DataIC50:  0.970nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210176(CHEMBL3924682)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210167(CHEMBL3917405)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210174(CHEMBL3915689)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210167(CHEMBL3917405)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210190(CHEMBL3964125)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210173(CHEMBL3972157)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210254(CHEMBL3980203)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210178(CHEMBL3933593)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210258(CHEMBL3920872)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210262(CHEMBL3951291)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210179(CHEMBL3942555)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210175(CHEMBL3945293)
Affinity DataIC50:  5nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM12103(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 11 | 4-te...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210178(CHEMBL3933593)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210261(CHEMBL3952364)
Affinity DataIC50:  9nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210167(CHEMBL3917405)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210167(CHEMBL3917405)
Affinity DataIC50:  10nMAssay Description:Inhibition of human TYK2 (V877 to C1187 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210167(CHEMBL3917405)
Affinity DataIC50:  10nMAssay Description:Inhibition of human JAK3 JH1 catalytic domain (I781 to S1124 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210175(CHEMBL3945293)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  20nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210262(CHEMBL3951291)
Affinity DataIC50:  28nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210173(CHEMBL3972157)
Affinity DataIC50:  30nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210253(CHEMBL3943650)
Affinity DataIC50: <39nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210260(CHEMBL3982857)
Affinity DataIC50: <39nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210263(CHEMBL3954183)
Affinity DataIC50: <39nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210189(CHEMBL3911929)
Affinity DataIC50: <39nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210265(CHEMBL3892860)
Affinity DataIC50: <39nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210264(CHEMBL3893970)
Affinity DataIC50: <39nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210255(CHEMBL3962918)
Affinity DataIC50: <39nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50210180(CHEMBL3981879)
Affinity DataIC50:  47nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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