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Found 628 with Last Name = 'yiotakis' and Initial = 'a'
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM21464(2-benzyl-3-{[1-(2-acetamido-4-methylpentanoyl)pyrr...)
Affinity DataKi:  0.130nM ΔG°:  -56.4kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50227856((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
TargetStromelysin-3(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50265077((S)-3-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of MMP11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
University of Athens

LigandPNGBDBM21471(2-benzyl-3-{[1-(2-acetamido-4-methylpentanamido)-2...)
Affinity DataKi:  0.300nMAssay Description:Inhibitor potencies toward bovine carboxypeptidase A (Sigma-Aldrich Co) were determined in 96-well microplates format. Activity was monitored by meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50183715(CHEMBL207305 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM21474(3-({1-[2-acetamido-3-(1H-imidazol-4-yl)propanoyl]p...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303321((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303319((S)-2-[(S)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.410nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078937((1-Benzyloxycarbonylamino-ethyl)-{3-benzylsulfanyl...)
Affinity DataKi: <0.5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
University of Athens

LigandPNGBDBM21464(2-benzyl-3-{[1-(2-acetamido-4-methylpentanoyl)pyrr...)
Affinity DataKi:  0.5nMAssay Description:Inhibitor potencies toward bovine carboxypeptidase A (Sigma-Aldrich Co) were determined in 96-well microplates format. Activity was monitored by meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26526((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of human somatic ACE in presence of bufferMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078947((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-ca...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM21470(2-benzyl-3-({1-[2-acetamido-3-(1H-imidazol-4-yl)pr...)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Mus musculus)
Cea

Curated by ChEMBL
LigandPNGBDBM50078935((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity against matrix metalloprotease-11.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50264776((2S,3R)-N1-hydroxy-N4-((1S,2R)-2-hydroxy-2,3-dihyd...)
Affinity DataKi: <1nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50216802((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303326((S)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human somatic ECE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM21473(3-{[1-(2-acetamido-4-methylpentanoyl)pyrrolidin-2-...)
Affinity DataKi:  1.25nM ΔG°:  -50.8kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303322((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303326((S)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human somatic NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Mus musculus)
Cea

Curated by ChEMBL
LigandPNGBDBM50078950((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against matrix metalloprotease-11.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078950((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Mus musculus)
Cea

Curated by ChEMBL
LigandPNGBDBM50078947((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-ca...)
Affinity DataKi:  2nMAssay Description:Binding affinity against matrix metalloprotease-11.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078930((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[(R)-...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50138684((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-ca...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078951(CHEMBL87159 | [1-(2-Benzyloxy-acetylamino)-2-pheny...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50265114(CHEMBL495502 | N-((2R,6S)-4-(2-(hydroxyamino)-2-ox...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303327((2S)-2-((1S,2S)-2-(((R)-1-(benzyloxycarbonylamino)...)
Affinity DataKi:  3nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50078947((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-ca...)
Affinity DataKi:  3nMAssay Description:Binding affinity against matrix metalloprotease-9 (gelatinase-B).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078943((1-Acetylamino-2-phenyl-ethyl)-{2-[1-carbamoyl-2-(...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303323((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303328((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1{[(benzyloxy)c...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human somatic ACE in presence of bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Mus musculus)
Cea

Curated by ChEMBL
LigandPNGBDBM50078945((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity against matrix metalloprotease-11.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303328((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1{[(benzyloxy)c...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  4nMAssay Description:Inhibition of human somatic ACE in presence of 1:100 diluted SHR rat plasmaMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078945((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  4nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078936(CHEMBL87786 | {2-[(2-Amino-1-carbamoyl-ethyl)-(2,4...)
Affinity DataKi:  4nMAssay Description:Inhibition of Matrix metalloprotease-7 MatrilysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Mus musculus)
Cea

Curated by ChEMBL
LigandPNGBDBM50078932((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity against matrix metalloprotease-11.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078953((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-ca...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078928((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50303325((2S)-2-{[3-(4',5'-Dihydro-3'-phenyl-5'-isoxazolyl)...)
Affinity DataKi:  5nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Mus musculus)
Cea

Curated by ChEMBL
LigandPNGBDBM50078951(CHEMBL87159 | [1-(2-Benzyloxy-acetylamino)-2-pheny...)
Affinity DataKi:  5nMAssay Description:Binding affinity against matrix metalloprotease-11.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50078935((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Mus musculus)
Cea

Curated by ChEMBL
LigandPNGBDBM50078938((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  5nMAssay Description:Binding affinity against matrix metalloprotease-11.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Mus musculus)
Cea

Curated by ChEMBL
LigandPNGBDBM50078930((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[(R)-...)
Affinity DataKi:  5nMAssay Description:Binding affinity against matrix metalloprotease-11.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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