Affinity DataIC50: 3.5nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation count...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 8nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant PDE3BMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant PDE3BMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant PDE3BMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 23nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 24nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 26nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair