Compile Data Set for Download or QSAR
maximum 50k data
Found 572 with Last Name = 'youngsaye' and Initial = 'w'
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528058(US11180482, Example I-39 | US11180482, Example I-4...)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528024(US11180482, Example I-6)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528058(US11180482, Example I-39 | US11180482, Example I-4...)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528057(US11180482, Example I-38)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528050(2-((5-chloro-2-((6-methoxy-2-methyl-1,2,3,4-tetrah...)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM243403(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528048(US11180482, Example I-29)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528043(US11180482, Example I-24)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528041(US11180482, Example I-22)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528040(US11180482, Example I-21)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528039(US11180482, Example I-20)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528038(US11180482, Example I-19)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528037(US11180482, Example I-18)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528030(US11180482, Example I-12)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528029(US11180482, Example I-11 | US11180482, Example I-4...)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528028(US11180482, Example I-10)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528059(US11180482, Example I-40)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528023(US11180482, Example I-5)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528020(US11180482, Example I-2)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528029(US11180482, Example I-11 | US11180482, Example I-4...)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50069751(CHEMBL2356114)
Affinity DataIC50:  5nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528065(US11180482, Example I-46)
Affinity DataIC50: <5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528033(US11180482, Example I-14)
Affinity DataIC50:  7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528042(US11180482, Example I-23)
Affinity DataIC50:  7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528067(US11180482, Example I-48)
Affinity DataIC50:  7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528025(US11180482, Example I-7)
Affinity DataIC50:  7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528026(US11180482, Example I-8)
Affinity DataIC50:  7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528063(US11180482, Example I-44)
Affinity DataIC50:  7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528051(US11180482, Example II-3)
Affinity DataIC50:  7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528046(US11180482, Example I-27)
Affinity DataIC50:  7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50615689(CHEMBL5283715)
Affinity DataIC50:  8nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615690(CHEMBL5286823)
Affinity DataIC50:  8nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615690(CHEMBL5286823)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant PDE3BMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615688(CHEMBL5280568)
Affinity DataIC50:  10nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615689(CHEMBL5283715)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant PDE3BMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609616(CHEMBL5291353)
Affinity DataIC50:  15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609613(CHEMBL5270000)
Affinity DataIC50:  15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609617(CHEMBL5284387)
Affinity DataIC50:  15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM15298(N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant PDE3BMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50069751(CHEMBL2356114)
Affinity DataIC50:  17nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM368373(US10227342, Example 9)
Affinity DataIC50:  19nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM368372(US10227342, Example 8)
Affinity DataIC50:  20nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50088281(CHEMBL3427475)
Affinity DataIC50:  23nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609615(CHEMBL5266834)
Affinity DataIC50:  23nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609607(CHEMBL5281266)
Affinity DataIC50:  23nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM15298(N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM368446(US10227342, Example 77)
Affinity DataIC50:  24nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615685(CHEMBL1495092)
Affinity DataIC50:  25nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50088195(CHEMBL3427497)
Affinity DataIC50:  26nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 572 total ) | Next | Last >>
Jump to: