BindingDB PrimarySearch_ki

Found 1522 with Last Name = 'yu' and Initial = 'r'

5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50607169(CHEMBL5220371)

Ki: 0.0690nMAssay Description:Displacement of [3H]8-OH-DAPT from 5-HT1A receptor in human HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50443101(Cariprazine | RGH-188)

Ki: 0.0850nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50607170(CHEMBL5220872)

Ki: 0.0970nMAssay Description:Displacement of [3H]8-OH-DAPT from 5-HT1A receptor in human HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50529312(CHEMBL4444213)

Ki: 0.200nMAssay Description:Displacement of [3H]8-OH-DAPT from 5-HT1A receptor in human HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Sigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

Curated by ChEMBL

PNG

BDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)

Ki: 0.440nMAssay Description:Binding affinity to Sigma 2-receptor (unknown origin)More data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

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D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50443101(Cariprazine | RGH-188)

Ki: 0.490nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549018(CHEMBL4799863)

Ki: 0.5nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)

Ki: 0.700nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Histamine H1 receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549038(CHEBI:71257 | CHEMBL504548)

Ki: 1nMAssay Description:Binding affinity to H1 histamine receptor (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549021(CHEMBL4797996)

Ki: 1.10nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549038(CHEBI:71257 | CHEMBL504548)

Ki: 1.20nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549019(CHEMBL4753808)

Ki: 1.20nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549032(CHEMBL4759975)

Ki: 1.5nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50472100(CHEMBL147922)

Ki: 1.5nMAssay Description:Displacement of [3H]8-OH-DAPT from 5-HT1A receptor in human HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549033(CHEMBL4741702)

Ki: 1.80nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

PNG

BDBM8061(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4...)

Ki: 2nM ΔG°: -50.5kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50443101(Cariprazine | RGH-188)

Ki: 2.60nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
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D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549032(CHEMBL4759975)

Ki: 2.80nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549033(CHEMBL4741702)

Ki: 2.90nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549025(CHEMBL4784751)

Ki: 3.30nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

PNG

BDBM8061(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4...)

Ki: 4nM ΔG°: -48.7kJ/molepH: 7.2 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549019(CHEMBL4753808)

Ki: 4.30nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549021(CHEMBL4797996)

Ki: 5.30nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549037(CHEMBL4752414)

Ki: 5.80nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549018(CHEMBL4799863)

Ki: 5.90nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549021(CHEMBL4797996)

Ki: 6.30nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549026(CHEMBL4762024)

Ki: 6.60nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549023(CHEMBL4788140)

Ki: 6.90nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50095890(2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...)

Ki: 7nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H1 receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)

Ki: 7nMAssay Description:Binding affinity to H1 histamine receptor (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549022(CHEMBL4750939)

Ki: 7.20nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549036(CHEMBL4761274)

Ki: 8.10nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549029(CHEMBL4756826)

Ki: 8.20nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Sigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

Curated by ChEMBL

PNG

BDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)

Ki: 8.5nMAssay Description:Binding affinity to Sigma 2-receptor (unknown origin)More data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

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Sigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

Curated by ChEMBL

PNG

BDBM50577481(CHEMBL4865307)

Ki: 9nMAssay Description:Binding affinity to Sigma 2-receptor (unknown origin)More data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549026(CHEMBL4762024)

Ki: 9.30nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549027(CHEMBL4741673)

Ki: 9.5nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549029(CHEMBL4756826)

Ki: 9.80nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

Histamine H1 receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50095890(2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...)

Ki: 11nMAssay Description:Binding affinity to H1 histamine receptor (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

Curated by ChEMBL

PNG

BDBM349513(US10207991, Ex. Cpd. No. 28 | US10611728, Example ...)

Ki: 11nMAssay Description:Binding affinity to Sigma 2-receptor (unknown origin)More data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)

Ki: 11nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50464867(CHEMBL4289783)

Ki: 12nMAssay Description:Displacement of [3H]8-OH-DAPT from 5-HT1A receptor in human HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549019(CHEMBL4753808)

Ki: 12nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

Max-like protein X(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50388975(CHEMBL2063869)

Ki: 14nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from MLXBIR3SG after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
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D(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549026(CHEMBL4762024)

Ki: 14nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549034(CHEMBL4743651)

Ki: 15nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549018(CHEMBL4799863)

Ki: 15nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549019(CHEMBL4753808)

Ki: 16nMAssay Description:Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Max-like protein X(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50388974(CHEMBL2063868)

Ki: 16nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from MLXBIR3SG after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

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D(3) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL

PNG

BDBM50549031(CHEMBL4755563)

Ki: 17nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

Displayed 1 to 50 (of 1522 total ) | Next | Last >>

Filter my 1522 hits

Targets 84▿
- Integrase 166
- Progesterone receptor 147
- Tyrosine-protein kinase JAK3 107
- Tyrosine-protein kinase JAK2 95
- Tyrosine-protein kinase JAK1 62
- Mitogen-activated protein kinase kinase kinase 5 51
- Low molecular weight protein-tyrosine phosphatase A 50
- Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 45
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 45
- Tyrosine-protein kinase BTK 40
- Dual specificity mitogen-activated protein kinase kinase 1 38
- Acetylcholinesterase 33
- Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 32
- Tyrosine-protein phosphatase non-receptor type 1 28
- 5-hydroxytryptamine receptor 1A 28
- Neuronal acetylcholine receptor; alpha9/alpha10 27
- MAP kinase-interacting serine/threonine-protein kinase 1 25
- Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251] 23
- Non-receptor tyrosine-protein kinase TYK2 23
- MAP kinase-interacting serine/threonine-protein kinase 2 23
- Casein kinase II subunit alpha/beta 22
- Broad substrate specificity ATP-binding cassette transporter ABCG2 22
- D(3) dopamine receptor 20
- Peptidyl-prolyl cis-trans isomerase FKBP1A 20
- D(2) dopamine receptor 20
- Envelope phospholipase F13 19
- Proto-oncogene tyrosine-protein kinase Src 19
- Tyrosine-protein phosphatase YopH 18
- TYR_PHOSPHATASE_2 domain-containing protein 18
- Androgen receptor 18
- Diacylglycerol O-acyltransferase 1 18
- Glutaminase kidney isoform, mitochondrial 16
- Mineralocorticoid receptor 15
- Glucocorticoid receptor 15
- Neuronal acetylcholine receptor subunit alpha-7 12
- Histamine H1 receptor 12
- Estrogen receptor 10
- E3 ubiquitin-protein ligase XIAP 9
- Sigma intracellular receptor 2 8
- Protein arginine N-methyltransferase 1 [11-371] 8
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 8
- Potassium voltage-gated channel subfamily H member 2 8
- Max-like protein X 8
- Dihydroorotate dehydrogenase (quinone), mitochondrial 6
- Envelope glycoprotein gp160 6
- Nicotinic acetylcholine receptor alpha9/alpha10 6
- Sodium-dependent serotonin transporter 5
- Hemagglutinin 4
- Aromatase 4
- Genome polyprotein 4
- 5-hydroxytryptamine receptor 2A 4
- Heat shock protein HSP 90-alpha 4
- Estrogen receptor beta 4
- Cytochrome P450 3A4 4
- Baculoviral IAP repeat-containing protein 2 2
- Acetyl-CoA acetyltransferase, mitochondrial 2
- ATP-binding cassette sub-family C member 8 2
- Neuronal acetylcholine receptor subunit alpha-3/beta-2 2
- Baculoviral IAP repeat-containing protein 3 2
- Tyrosine-protein phosphatase non-receptor type 2 2
- JAK3/JAK1 2
- Ribosyldihydronicotinamide dehydrogenase [quinone] 2
- Tyrosine-protein phosphatase non-receptor type 11 2
- Soluble acetylcholine receptor 2
- Protein arginine N-methyltransferase 5 1
- Protein arginine N-methyltransferase 6 1
- Eukaryotic translation initiation factor 4E 1
- Substance-P receptor 1
- Histone-arginine methyltransferase CARM1 1
- Protein kinase C alpha type 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Substance-K receptor 1
- Cannabinoid receptor 1 1
- Adenosine receptor A1 1
- Gastrin/cholecystokinin type B receptor 1
- Beta-1 adrenergic receptor 1
- Neuraminidase 1
- Cyclin-H/Cyclin-dependent kinase 7 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Poly [ADP-ribose] polymerase 1 1
- 5-hydroxytryptamine receptor 7 1
- Casein kinase II subunit alpha 1
- Alpha-2A adrenergic receptor 1
- Glycogen synthase kinase-3 beta 1
- ...
Publications 50▿
- Bioorg Med Chem 15: 4985-5002 (2007) 166
- Bioorg Med Chem 27: 1562-1576 (2019) 102
- Bioorg Med Chem 26: 4774-4786 (2018) 98
- Bioorg Med Chem 27: 1646-1657 (2019) 95
- Bioorg Med Chem Lett 31: (2021) 77
- J Med Chem 47: 1662-75 (2004) 66
- J Med Chem 55: 390-402 (2012) 55
- Bioorg Med Chem Lett 18: 5015-7 (2008) 55
- Bioorg Med Chem 16: 6589-600 (2008) 51
- Eur J Med Chem 61: 104-15 (2013) 43
- US Patent US9540396 (2017) 38
- US Patent US9926299 (2018) 34
- Bioorg Med Chem Lett 25: 3458-63 (2015) 32
- Bioorg Med Chem Lett 14: 4237-40 (2004) 30
- Bioorg Med Chem Lett 22: 7119-22 (2012) 27
- Bioorg Med Chem Lett 19: 6666-9 (2009) 26
- Eur J Med Chem 219: (2021) 25
- J Nat Prod 72: 1944-8 (2009) 25
- Bioorg Med Chem Lett 20: 4816-8 (2010) 25
- Eur J Med Chem 84: 382-94 (2014) 23
- J Med Chem 57: 2930-41 (2014) 22
- J Nat Prod 69: 432-5 (2006) 22
- RSC Med Chem 13: 1644-1656 (2022) 22
- J Enzyme Inhib Med Chem 29: 338-43 (2014) 22
- Eur J Med Chem 134: 24-33 (2017) 21
- J Med Chem 55: 4101-13 (2012) 21
- J Med Chem 43: 1135-42 (2000) 20
- Bioorg Med Chem Lett 62: (2022) 20
- J Med Chem 63: 2974-2985 (2020) 20
- Eur J Med Chem 221: (2021) 19
- Bioorg Med Chem 18: 3783-9 (2010) 19
- Eur J Med Chem 64: 35-41 (2013) 18
- J Med Chem 61: 4628-4634 (2018) 16
- ACS Med Chem Lett 12: 1389-1395 (2021) 15
- Bioorg Med Chem Lett 11: 1665-9 (2001) 13
- Bioorg Med Chem Lett 25: 5449-53 (2015) 11
- Bioorg Med Chem Lett 76: (2022) 11
- J Med Chem 65: 16204-16217 (2022) 8
- J Med Chem 54: 2680-6 (2011) 8
- RSC Med Chem 11: 307-316 (2020) 8
- Chem Biol Drug Des 86: 626-36 (2015) 6
- Bioorg Med Chem Lett 9: 2353-8 (1999) 6
- Bioorg Med Chem Lett 28: 49-52 (2018) 6
- J Nat Prod 74: 129-36 (2011) 6
- Bioorg Med Chem Lett 18: 6227-30 (2008) 5
- Eur J Med Chem 135: 24-33 (2017) 4
- J Med Chem 63: 6924-6940 (2020) 4
- Bioorg Med Chem Lett 16: 3337-40 (2006) 4
- J Med Chem 56: 3557-67 (2013) 3
- Eur J Med Chem 185: (2020) 3
Institutions 33▿
- China Pharmaceutical University 295
- University Of Southern California 166
- Wyeth Research 157
- Universidade Federal De Santa Catarina 97
- Cyclacel 96
- Shanghai Institute Of Pharmaceutical Industry 88
- Centaurus Biopharma 72
- Pfizer 52
- Nas Of Ukraine 51
- Ocean University Of China 48
- Guangzhou Institutes Of Biomedicine And Health 32
- Ocean University Of China And Laboratory For Marine Drugs And Bioproducts 25
- Aurigene Discovery Technologies 23
- Bmssi Umr 5086 Cnrs/Universit£ 22
- Nas of Ukraine 22
- Tom'S Of Maine 22
- Federal University Of Santa Catarina 22
- Genentech 21
- Chinese Academy Of Sciences 21
- Ariad Gene Therapeutics 20
- Dr.Vishwanath Karad Mit World Peace University 20
- Ariad Pharmaceuticals 19
- Samara State Technical University 19
- Cognition Therapeutics 15
- Sichuan University 11
- School Of Health Sciences/Graduate Program In Pharmaceutical Sciences 8
- Chinese Academy of Sciences 6
- Yunnan Normal University 6
- Renmin Hospital Of Wuhan University 6
- Sunway University College 4
- Ocean University of China 4
- The University Of Queensland 3
- Kazan Scientific Center Of The Russian Academy Of Sciences 3
Affinity: 0.069 to 6.1E+7 nM▿
- Ki 240
- IC50 1192
- Kd 10
- EC50 80
- Affinity ≤ nM
Xtal structures: 36
Docked structures: 31
Catalog Cmpds: 238