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Found 2360 with Last Name = 'yuan' and Initial = 'h'
TargetDihydrofolate reductase(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50457437(CHEBI:71223 | Folotyn | PDX | Pralatrexate)
Affinity DataKi:  0.0130nMAssay Description:Inhibition of DHFR (unknown origin) at pH 6.7More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0350nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0610nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162983(6-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-3-yl]...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50097613(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-phenylet...)
Affinity DataKi:  0.510nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.570nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162987(6-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162988(3-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...)
Affinity DataKi:  0.930nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162984(3-(6-Fluoro-hex-1-ynyl)-5-((S)-1-methyl-pyrrolidin...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50027656(CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of thymidylate synthase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162982(3-Hex-1-ynyl-5-((S)-1-methyl-pyrrolidin-2-ylmethox...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162986(3-Ethynyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Affinity DataKi:  1.70nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049756(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Affinity DataKi:  2.40nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162985(2-Methyl-4-[5-((S)-1-methyl-pyrrolidin-2-ylmethoxy...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604776(CHEMBL5207224)
Affinity DataKi:  3.80nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50125136(2-[2,3']Bipyridinyl-6'-yl-1-(2,3-dihydro-benzofura...)
Affinity DataKi:  4nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600600(CHEMBL5207885)
Affinity DataKi:  4.30nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162989(10-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridi...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604771(CHEMBL5169868)
Affinity DataKi:  6.90nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162988(3-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...)
Affinity DataKi:  7.10nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50027656(CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...)
Affinity DataKi:  7.20nMAssay Description:Inhibition of DHFR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049756(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Affinity DataKi:  7.70nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162986(3-Ethynyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50097613(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-phenylet...)
Affinity DataKi:  8.60nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50118253(1-Benzo[1,3]dioxol-5-yl-2-[5-(3,4-dimethoxy-phenyl...)
Affinity DataKi:  8.90nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600605(CHEMBL5208751)
Affinity DataKi:  9nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604774(CHEMBL5189068)
Affinity DataKi:  10nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600607(CHEMBL5207405)
Affinity DataKi:  10nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  10nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604770(CHEMBL5173331)
Affinity DataKi:  11nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604777(CHEMBL5180200)
Affinity DataKi:  12nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600603(CHEMBL5192961)
Affinity DataKi:  12nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600611(CHEMBL5199628)
Affinity DataKi:  12nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600604(CHEMBL5193621)
Affinity DataKi:  13nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162987(6-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604775(CHEMBL5198918)
Affinity DataKi:  13nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162984(3-(6-Fluoro-hex-1-ynyl)-5-((S)-1-methyl-pyrrolidin...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50304090(CHEMBL594615 | N-(4-(3-(2-(3,4-Dichlorophenylamino...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600601(CHEMBL5181318)
Affinity DataKi:  18nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162982(3-Hex-1-ynyl-5-((S)-1-methyl-pyrrolidin-2-ylmethox...)
Affinity DataKi:  21nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162985(2-Methyl-4-[5-((S)-1-methyl-pyrrolidin-2-ylmethoxy...)
Affinity DataKi:  23nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600610(CHEMBL5179440)
Affinity DataKi:  23nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600609(CHEMBL5172250)
Affinity DataKi:  26nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604772(CHEMBL5171014)
Affinity DataKi:  31nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604778(CHEMBL5172177)
Affinity DataKi:  31nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50600612(CHEMBL5187046)
Affinity DataKi:  35nMAssay Description:Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50604773(CHEMBL5182998)
Affinity DataKi:  39nMAssay Description:Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  47nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
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