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Found 178 with Last Name = 'yun' and Initial = 'l'
TargetTranslocator protein(Rattus norvegicus (rat))
Toxicology Academy of Military Medical Sciences P.L.A.

US Patent
LigandPNGBDBM150169(US8980887, Compound 13)
Affinity DataKi:  2.97nM ΔG°:  -49.5kJ/mole IC50:  6.99nMT: 2°CAssay Description:Competitive Binding Test of Drug to the Receptor (Rat Heart TSPO) and Radioligand (3H-PK11195): (1) tubes were placed in reaction condition of 30 C.(...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Toxicology Academy of Military Medical Sciences P.L.A.

US Patent
LigandPNGBDBM150168(US8980887, Compound 11)
Affinity DataKi:  6.66nM ΔG°:  -47.5kJ/mole IC50:  15.6nMT: 2°CAssay Description:Competitive Binding Test of Drug to the Receptor (Rat Heart TSPO) and Radioligand (3H-PK11195): (1) tubes were placed in reaction condition of 30 C.(...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Toxicology Academy of Military Medical Sciences P.L.A.

US Patent
LigandPNGBDBM150164(US8980887, Compound 1)
Affinity DataKi:  7.17nM ΔG°:  -47.3kJ/mole IC50:  16.9nMT: 2°CAssay Description:Competitive Binding Test of Drug to the Receptor (Rat Heart TSPO) and Radioligand (3H-PK11195): (1) tubes were placed in reaction condition of 30 C.(...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Toxicology Academy of Military Medical Sciences P.L.A.

US Patent
LigandPNGBDBM150166(US8980887, Compound 8)
Affinity DataKi:  9.34nM ΔG°:  -46.6kJ/mole IC50:  21.9nMT: 2°CAssay Description:Competitive Binding Test of Drug to the Receptor (Rat Heart TSPO) and Radioligand (3H-PK11195): (1) tubes were placed in reaction condition of 30 C.(...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Toxicology Academy of Military Medical Sciences P.L.A.

US Patent
LigandPNGBDBM150167(US8980887, Compound 10)
Affinity DataKi:  11.1nM ΔG°:  -46.2kJ/mole IC50:  26.1nMT: 2°CAssay Description:Competitive Binding Test of Drug to the Receptor (Rat Heart TSPO) and Radioligand (3H-PK11195): (1) tubes were placed in reaction condition of 30 C.(...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Toxicology Academy of Military Medical Sciences P.L.A.

US Patent
LigandPNGBDBM150170(US8980887, Compound 14)
Affinity DataKi:  38.7nM ΔG°:  -43.0kJ/mole IC50:  91.0nMT: 2°CAssay Description:Competitive Binding Test of Drug to the Receptor (Rat Heart TSPO) and Radioligand (3H-PK11195): (1) tubes were placed in reaction condition of 30 C.(...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Toxicology Academy of Military Medical Sciences P.L.A.

US Patent
LigandPNGBDBM150165(US8980887, Compound 7)
Affinity DataKi:  49.2nM ΔG°:  -42.4kJ/mole IC50:  116nMT: 2°CAssay Description:Competitive Binding Test of Drug to the Receptor (Rat Heart TSPO) and Radioligand (3H-PK11195): (1) tubes were placed in reaction condition of 30 C.(...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Institute Of The Chemistry Of Plant Substances

Curated by ChEMBL
LigandPNGBDBM50321104(CHEMBL1163804 | DFGYVAE)
Affinity DataKi:  51nMAssay Description:Competitive inhibition of HMG-CoA reductase by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Institute Of The Chemistry Of Plant Substances

Curated by ChEMBL
LigandPNGBDBM50321100(CHEMBL1164546 | GF(4-fluro)PTGG)
Affinity DataKi:  260nMAssay Description:Competitive inhibition of HMG-CoA reductase by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50023492(5-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazo...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310205(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310235(3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50023492(5-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazo...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Beijing Institute Of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)
Affinity DataIC50: <10nMAssay Description:Inhibition of HIV1 recombinant proteaseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310214(2-(3-Bromophenyl)-7-(3'-cyclopropylmethoxy-4'-difl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute Of Pharmacology And Toxicology

Curated by ChEMBL
LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human BACE1 proteolytic activityMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Crystalgenomics

Curated by ChEMBL
LigandPNGBDBM50220373(2-(2,4-DICHLORO-PHENYL)-7-HYDROXY-1H-BENZOIMIDAZOL...)
Affinity DataIC50:  15nMAssay Description:Inhibition of GSK3beta at 5 uMMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute Of Pharmacology And Toxicology

Curated by ChEMBL
LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310226(Acetic acid 3-[7-(3'-cyclopropylmethoxy-4'-difluor...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50023505(2-Furan-2-yl-9-methoxy-[1,2,4]triazolo[1,5-c]quina...)
Affinity DataIC50:  19nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute Of Pharmacology And Toxicology

Curated by ChEMBL
LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  19.9nMAssay Description:Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310210(7-(3'-Cyclopentyloxy-4'-methoxyphenyl)-2-(3-chloro...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310225(3-(7-(3-(cyclopropylmethoxy)-4-methoxyphenyl)pyraz...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataIC50:  21nMAssay Description:Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50023495(2-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Affinity DataIC50:  21nMAssay Description:Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50023500((9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quina...)
Affinity DataIC50:  22nMAssay Description:Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310240(3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Crystalgenomics

Curated by ChEMBL
LigandPNGBDBM50220369(CHEMBL399140 | N-(4-(methylsulfonamido)phenethyl)-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of GSK3beta at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310244(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50023496(2-Furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl...)
Affinity DataIC50:  27nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310204(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310238(3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute Of Pharmacology And Toxicology

Curated by ChEMBL
LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  29nMAssay Description:Inhibition of BACE1 expressed in HEK293T cells co-transfected APP with NFEV mutation at proteolytic site by sAPP_NF cell based assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310245(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310213(7-(3'-Cyclopentyloxy-4'-methoxyphenyl)-2-(2,5-dich...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310215(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310211(2-(3-Bromophenyl)-7-(3'-cyclopentyloxy-4'-methoxyp...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50023505(2-Furan-2-yl-9-methoxy-[1,2,4]triazolo[1,5-c]quina...)
Affinity DataIC50:  31nMAssay Description:Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310246(5-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310223(2-(3-(allyloxy)phenyl)-7-(3-(cyclopropylmethoxy)-4...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310229(CHEMBL603230 | N-{3-[7-(3'-Cyclopropylmethoxy-4'-d...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310220(2-(3-Chlorophenyl)-7-(3'-cyclopropylmethoxy-4'-dif...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310216(3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50023496(2-Furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl...)
Affinity DataIC50:  38nMAssay Description:Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310241(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310212(7-(3'-Cyclopentyloxy-4'-methoxyphenyl)-2-(3-methox...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310228(CHEMBL598049 | {3-[7-(3'-Cyclopropylmethoxy-4'-dif...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310230(3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310236(3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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