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Found 1976 with Last Name = 'zheng' and Initial = 's'
TargetCoagulation factor XI(Homo sapiens (Human))
Sichuan Haisco Pharmaceutical

US Patent
LigandPNGBDBM320260(US10174020, Compound 8-1)
Affinity DataKi:  2nMAssay Description:The following method was used to test the in vitro inhibitory effect of the compounds of the present invention on the activity of human blood-coagula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277511(3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromet...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277511(3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromet...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386351(CHEMBL2048589)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386346(CHEMBL2048594)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386346(CHEMBL2048594)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386364(CHEMBL2048592)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386346(CHEMBL2048594)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386346(CHEMBL2048594)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Sichuan Haisco Pharmaceutical

US Patent
LigandPNGBDBM320262(5-[[2-[4-[5-chloro-2-(tetrazol-1-yl)phenyl]-2-oxo-...)
Affinity DataKi:  4nMAssay Description:The following method was used to test the in vitro inhibitory effect of the compounds of the present invention on the activity of human blood-coagula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386351(CHEMBL2048589)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50432672(CHEMBL2347912)
Affinity DataKi:  5.60nMAssay Description:Inhibition of human microsomal CYP1B1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386364(CHEMBL2048592)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386347(CHEMBL2048595)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Sichuan Haisco Pharmaceutical

US Patent
LigandPNGBDBM320255(N-(2-carboxyindol-5-yl)-7-(5-chloro-2-(1H-tetrazol...)
Affinity DataKi:  9nMAssay Description:The following method was used to test the in vitro inhibitory effect of the compounds of the present invention on the activity of human blood-coagula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386350(CHEMBL2048590)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386353(CHEMBL2048587)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Sichuan Haisco Pharmaceutical

US Patent
LigandPNGBDBM320258(N-(2-carboxyindol-5-yl)-2-(4-(5-chloro-2-(1H-tetra...)
Affinity DataKi:  14nMAssay Description:The following method was used to test the in vitro inhibitory effect of the compounds of the present invention on the activity of human blood-coagula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50432672(CHEMBL2347912)
Affinity DataKi:  14nMAssay Description:Inhibition of human microsomal CYP1A2-dependent methoxyresorufin-O-demethylase activity by spectrofluorimetric analysis in presence of NADPH regenera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386352(CHEMBL2048588)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386359(CHEMBL2048581)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataKi:  16nMAssay Description:Inhibition of human microsomal CYP1B1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerati...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386347(CHEMBL2048595)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Sichuan Haisco Pharmaceutical

US Patent
LigandPNGBDBM320256(N-(2-carboxyindol-5-yl)-2-(5-chloro-2-(1H-tetrazol...)
Affinity DataKi:  17nMAssay Description:The following method was used to test the in vitro inhibitory effect of the compounds of the present invention on the activity of human blood-coagula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386359(CHEMBL2048581)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataKi:  20nMAssay Description:Inhibition of human microsomal CYP1A2-dependent methoxyresorufin-O-demethylase activity by spectrofluorimetric analysis in presence of NADPH regenera...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386362(CHEMBL2048412)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50113259(CHEMBL3601433)
Affinity DataKi:  30nMAssay Description:Inhibition of human microsomal CYP1A2-dependent methoxyresorufin-O-demethylase activity by spectrofluorimetric analysis in presence of NADPH regenera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386362(CHEMBL2048412)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386363(CHEMBL2048411)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386346(CHEMBL2048594)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386354(CHEMBL2048586)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386357(CHEMBL2048583)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50113261(CHEMBL3601435)
Affinity DataKi:  40nMAssay Description:Inhibition of human microsomal CYP1A1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50113260(CHEMBL3601434)
Affinity DataKi:  44nMAssay Description:Inhibition of human microsomal CYP1A2-dependent methoxyresorufin-O-demethylase activity by spectrofluorimetric analysis in presence of NADPH regenera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386352(CHEMBL2048588)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataKi:  45nMAssay Description:Inhibition of human microsomal CYP1A1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerati...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386357(CHEMBL2048583)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386356(CHEMBL2048584)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50333504(1-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386353(CHEMBL2048587)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50333504(1-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50432677(CHEMBL2347756)
Affinity DataKi:  53nMAssay Description:Inhibition of human microsomal CYP1B1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386363(CHEMBL2048411)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386354(CHEMBL2048586)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386349(CHEMBL2048591)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386350(CHEMBL2048590)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386349(CHEMBL2048591)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50386355(CHEMBL2048585)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Xavier University Of Louisiana

Curated by ChEMBL
LigandPNGBDBM50432677(CHEMBL2347756)
Affinity DataKi:  58nMAssay Description:Inhibition of human microsomal CYP1A2-dependent methoxyresorufin-O-demethylase activity by spectrofluorimetric analysis in presence of NADPH regenera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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