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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataKi:  3.40nMAssay Description:Displacement of radioligand from human CRTH2 expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataKi: >3.80E+4nMAssay Description:Displacement of radioligand from prostanoid DP receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataKi: >7.10E+4nMAssay Description:Displacement of radioligand from prostanoid TP receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at CRTH2 in human eosinophil assessed as effect of cellular shape change by EOS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataIC50:  5.70nMAssay Description:Antagonist activity at human CRTH2 expressed in HEK293 cells assessed as inhibition of forskolin-induced increase intracellular [125I]cAMP level by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed