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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
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Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263463
((s)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
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Affinity Data
Ki: 179nM ΔG°: -35.8kJ/mole
pH: 7.4 T: 2°C
Assay Description:
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263463
((s)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
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Copy InChI
Affinity Data
Ki: 179nM
Assay Description:
Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263463
((s)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 179nM
Assay Description:
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263463
((s)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.79E+5nM
Assay Description:
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI