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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
18
hits in this display
Target
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 0.300nM
Assay Description:
Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...
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Target
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 3.10nM
Assay Description:
Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...
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KEGG
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antibodypedia
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PubMed
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3D Structure (crystal)
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 36nM
Assay Description:
Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...
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Target Info
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PubMed
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3D Structure (crystal)
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
Copy SMILES
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Affinity Data
IC50: 36nM
Assay Description:
Inhibition of TNKS1 (unknown origin)
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of South Australia
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 39nM
Assay Description:
Inhibition of TNKS2 (unknown origin)
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Target Info
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of South Australia
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 39nM
Assay Description:
Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 1.24E+3nM
Assay Description:
Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 1.24E+3nM
Assay Description:
Inhibition of PAPR2 (unknown origin)
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 8.05E+3nM
Assay Description:
Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to...
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to...
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Target Info
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 t...
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Target Info
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Target
Cytochrome P450 2B6
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to...
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Target Info
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH addition and measured fo...
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Target Info
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 t...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Cytochrome P450 2C8
(Homo sapiens (Human))
Japanese Foundation For Cancer Research
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 ...
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of South Australia
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
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Affinity Data
IC50: 1.82E+4nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
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Ligand Info
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In Depth
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PubMed
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of South Australia
Curated by
ChEMBL
Ligand
BDBM50511548
(CHEMBL4449082)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.82E+4nM
Assay Description:
Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
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Article
PubMed
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