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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
21
hits in this display
Target
Proteasome subunit beta type-9
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 2.70nM
Assay Description:
Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and m...
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Target
Proteasome subunit beta type-8
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 2.90nM
Assay Description:
Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...
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Target
Proteasome subunit beta type-5
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 2.90nM
Assay Description:
Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...
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Target
Proteasome subunit beta type-1
(Homo sapiens (Human))
Hangzhou Xixi Hospital
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 3nM
Assay Description:
Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assay
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Target
Proteasome subunit beta type-5
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 3.40nM
Assay Description:
Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta5 after 30 mins by fluorogenic assay
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Target
Proteasome subunit beta type-5
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 3.40nM
Assay Description:
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
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Target
Proteasome subunit beta type-5
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 3.40nM
Assay Description:
Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by fluorescence based assay
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Target
Proteasome subunit beta type-5
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured a...
More data for this Ligand-Target Pair
Target Info
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Target
Proteasome subunit beta type-5
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 7.70nM
Assay Description:
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...
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Target
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human))
University Of Auckland
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 15nM
Assay Description:
Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assay
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Target
Proteasome subunit beta type-2
(Homo sapiens (Human))
Hangzhou Xixi Hospital
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 30nM
Assay Description:
Inhibition of 20S proteasome beta 2c (unknown origin) after 1 hr by fluorescence based assay
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Target
Proteasome subunit beta type-1
(Homo sapiens (Human))
Hangzhou Xixi Hospital
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 31nM
Assay Description:
In vitro relative blocking action (pA2) of the post-synaptic Alpha-1 adrenergic receptor from rat and rabbit aorta
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Target
Proteasome subunit beta type-1
(Homo sapiens (Human))
Hangzhou Xixi Hospital
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
Copy SMILES
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Affinity Data
IC50: 31nM
Assay Description:
Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay
More data for this Ligand-Target Pair
Target Info
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Target
Proteasome subunit beta type-6
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 64nM
Assay Description:
Inhibition of human 20S immunoproteasome beta1 subunit using Ac-nLPnLD-AMC as substrate preincubated for 2 hrs followed by substrate addition and mea...
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Target
NACHT, LRR and PYD domains-containing protein 3
(Mus musculus)
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...
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Target
Proteasome subunit beta type-2
(Homo sapiens (Human))
Hangzhou Xixi Hospital
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 3.50E+3nM
Assay Description:
Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta2 after 30 mins by fluorogenic assay
More data for this Ligand-Target Pair
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Target
Proteasome subunit beta type-2
(Homo sapiens (Human))
Hangzhou Xixi Hospital
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 3.50E+3nM
Assay Description:
Inhibition of human platelet Thromboxane synthetase
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Target
Proteasome subunit beta type-10
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 4.87E+3nM
Assay Description:
Inhibition of human 20S immunoproteasome beta-2i subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and meas...
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Target
ATP-dependent Clp protease proteolytic subunit
(Staphylococcus aureus (strain NCTC 8325))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: 5.30E+3nM
Assay Description:
Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be...
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Target
Proteasome subunit beta type-7
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of human 20S proteasome beta2 subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured aft...
More data for this Ligand-Target Pair
Target Info
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Target
ATP-dependent Clp protease proteolytic subunit
(Staphylococcus aureus (strain NCTC 8325))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
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Affinity Data
EC50: 3.60E+3nM
Assay Description:
Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocyte...
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