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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 14 hits in this display   

TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 5 mM KPi concentration of bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  5.20E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  5.25E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity against beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 50 mM KPi concentration of bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity against Amp C beta-LactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 500 mMKPi concentration of bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  1.00E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  1.69E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  1.85E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  2.42E+4nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibitory activity against cloned Dihydrofolate reductase (cDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibitory activity against chymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of Beta-galactosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed