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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetcGMP-dependent protein kinase()
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM340924(1-isopropyl-3-(6-(2-methyl-5- (trifluoromethyl)ben...)
Affinity DataIC50:  52.2nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For

US Patent
LigandPNGBDBM340924(1-isopropyl-3-(6-(2-methyl-5- (trifluoromethyl)ben...)
Affinity DataIC50:  52.2nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For

US Patent
LigandPNGBDBM340924(1-isopropyl-3-(6-(2-methyl-5- (trifluoromethyl)ben...)
Affinity DataIC50:  52.2nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University of Washington Through Its Center For

US Patent
LigandPNGBDBM340924(1-isopropyl-3-(6-(2-methyl-5- (trifluoromethyl)ben...)
Affinity DataIC50:  197nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM340924(1-isopropyl-3-(6-(2-methyl-5- (trifluoromethyl)ben...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM340924(1-isopropyl-3-(6-(2-methyl-5- (trifluoromethyl)ben...)
Affinity DataIC50:  1.03E+3nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For

US Patent
LigandPNGBDBM340924(1-isopropyl-3-(6-(2-methyl-5- (trifluoromethyl)ben...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University of Washington Through Its Center For

US Patent
LigandPNGBDBM340924(1-isopropyl-3-(6-(2-methyl-5- (trifluoromethyl)ben...)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent