Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 23 hits in this display   

TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataKi:  1nMAssay Description:Inhibition of PGD2-induced CRTH2 receptor internalization of CD16 negative granulocytes in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataKi:  148nMAssay Description:Antagonist activity at DP receptor in human platelets assessed as inhibition of PGD2-induced cAMP production by competitive ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataKi:  4.40E+4nMAssay Description:Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataKi:  4.40E+4nMAssay Description:Inhibition of EP4 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Cavia porcellus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-PGD2 from guinea pig CRTH2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK 293 cells in presence of 0.5% BSA by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-PGD2 from human DP receptor expressed in HEK 293 cells in presence of 0.5% BSA by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 50% plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  280nMAssay Description:Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  280nMAssay Description:Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  280nMAssay Description:Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50:  3.00E+4nMAssay Description:Displacement of [3H]SQ29548 from human TP receptor transfected in HEK 293 EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed