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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
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Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263435
((s)?n-(1-(4-ethoxyphenyl)ethyl)-2-(4-oxobenzo[d][1...)
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Affinity Data
Ki: 953nM ΔG°: -31.9kJ/mole
pH: 7.4 T: 2°C
Assay Description:
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263435
((s)?n-(1-(4-ethoxyphenyl)ethyl)-2-(4-oxobenzo[d][1...)
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Copy InChI
Affinity Data
Ki: 953nM
Assay Description:
Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263435
((s)?n-(1-(4-ethoxyphenyl)ethyl)-2-(4-oxobenzo[d][1...)
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Copy InChI
Affinity Data
Ki: 953nM
Assay Description:
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263435
((s)?n-(1-(4-ethoxyphenyl)ethyl)-2-(4-oxobenzo[d][1...)
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Copy InChI
Affinity Data
Ki: 9.53E+5nM
Assay Description:
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Probable G-protein coupled receptor 139
(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Ligand
BDBM263435
((s)?n-(1-(4-ethoxyphenyl)ethyl)-2-(4-oxobenzo[d][1...)
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Copy InChI
Affinity Data
EC50: 67nM
Assay Description:
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI