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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
25
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: 14nM
Assay Description:
Inhibition of human TNKS2 (873 to 1162 residues) measured after 20 hrs in presence of NAD+ by fluorescence assay
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Target
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: 19nM
Assay Description:
Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo lucifer...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: 126nM
Assay Description:
Inhibition of recombinant human TNKS1 (1030 to 1317 residues) incubated for 20 hrs in presence of NAD
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
Copy SMILES
Copy InChI
Affinity Data
IC50: 127nM
Assay Description:
Inhibition of recombinant human TNKS1 (1030 to 1317 residues) incubated for 20 hrs in presence of NAD
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
Copy SMILES
Copy InChI
Affinity Data
IC50: 127nM
Assay Description:
Inhibition of human TNKS1 (1030 to 1317 residues) measured after 20 hrs in presence of NAD+ by fluorescence assay
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of N-terminal His-tagged human ARTD4 (250 to 565 residues) expressed in Escherichia coli Rosetta2 (DE3) using TCEP as substrate after 2.5 ...
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of N-terminal His-tagged human ARTD7 (482 to 678 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 3 h...
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD8 (1535 to 1801 residues) expressed in Escherichia coli Rosetta2 (DE3) after 21 hrs i...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...
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Target
Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD12 (469 to 701 residues) expressed in Escherichia coli Rosetta2 (DE3) after 20 hrs in...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP1 (unknown origin) incubated for 30 mins in presence of NAD
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP2 (unknown origin) incubated for 30 mins in presence of NAD
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP3 (unknown origin) incubated for 4 hrs in presence of NAD
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP4 (unknown origin)
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP10 (unknown origin)
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
Copy SMILES
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of ARTD3 (unknown origin) measured after 4 hrs in presence of NAD+ by fluorescence assay
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of ARTD2 (unknown origin) measured after 30 mins in presence of NAD+ by fluorescence assay
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of ARTD1 (unknown origin) measured after 30 mins in presence of NAD+ by fluorescence assay
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP14 (unknown origin)
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Target
Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP12 (unknown origin)
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
University Of Oslo
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP15 (unknown origin)
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >2.50E+4nM
Assay Description:
Inhibition of human ERG
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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IC50: >2.50E+4nM
Assay Description:
Inhibition of CYP3A4 (unknown origin) by LC-MS/MS analysis
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
Copy SMILES
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Affinity Data
IC50: >2.50E+4nM
Assay Description:
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS/MS analysis
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Symeres
Curated by
ChEMBL
Ligand
BDBM50541697
(CHEMBL4633637)
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Affinity Data
IC50: >2.50E+4nM
Assay Description:
Displacement of [3H]dofetilide from recombinant human ERG measured after 60 mins by scintillation counting method
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