Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257137(CHEMBL4094309)Copy SMILESCopy InChI

Affinity DataIC50:  15nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetStefin-3(Mus musculus)TBA

LigandBDBM50257137(CHEMBL4094309)Copy SMILESCopy InChI

Affinity DataIC50:  15nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPatentsSimilars

In DepthDetails PubMed
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TargetCytochrome P450 3A4(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257137(CHEMBL4094309)Copy SMILESCopy InChI

Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetCytochrome P450 2D6(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257137(CHEMBL4094309)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI