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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
99
hits in this display
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 0.190nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 0.200nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 0.410nM
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 0.450nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.960nM
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 0.960nM
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 1.10nM
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Target
Dopamine receptor D4
(CANINE)
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 1.20nM
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 1.30nM
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(BOVINE)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 2.10nM
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(BOVINE)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 2.10nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 2.20nM
Assay Description:
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 2.60nM
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.63nM
More data for this Ligand-Target Pair
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Target
Dopamine receptor D4
(CANINE)
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 3nM
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Target
Emopamil-binding protein-like
(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 3.90nM
Assay Description:
Binding affinity to emopamil binding protein (unknown origin)
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 3.98nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4nM
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 5.20nM
Assay Description:
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.40nM
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Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
(Homo sapiens (Human))
University Of Innsbruck
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 8nM
Assay Description:
Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 13nM
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 14.1nM
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
University Of Innsbruck
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 15nM
Assay Description:
Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand
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Target
D(4) dopamine receptor
(RAT)
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 19nM
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 23.8nM
More data for this Ligand-Target Pair
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 24nM
More data for this Ligand-Target Pair
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 24nM
More data for this Ligand-Target Pair
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 29nM
Assay Description:
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
Maryland Psychiatric Research Center
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 32.2nM
More data for this Ligand-Target Pair
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
Maryland Psychiatric Research Center
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 44nM
More data for this Ligand-Target Pair
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
Maryland Psychiatric Research Center
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 44nM
More data for this Ligand-Target Pair
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 44nM
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 62nM
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 62.5nM
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 63nM
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 6
(RAT)
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 66nM
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5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 80nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 100nM
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 118nM
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 135nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
Maryland Psychiatric Research Center
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 158nM
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Target
Alpha-2B adrenergic receptor
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 164nM
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 170nM
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Target
Histamine H1 receptor
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 182nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
Maryland Psychiatric Research Center
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 197nM
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Target
5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 291nM
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Target
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 345nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 378nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 378nM
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Target
Alpha-2C adrenergic receptor
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 392nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 411nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus
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Target
C-8 sterol isomerase ERG2
(Saccharomyces cerevisiae)
University Of Innsbruck
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 500nM
Assay Description:
Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 654nM
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 660nM
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 667nM
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Target
D(1A) dopamine receptor
(BOVINE)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 740nM
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Target
D(1A) dopamine receptor
(BOVINE)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: 740nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 850nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 950nM
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 1.00E+3nM
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Target
5-hydroxytryptamine receptor 7
(GUINEA PIG)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 1.45E+3nM
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 2.60E+3nM
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 2.63E+3nM
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 4.40E+3nM
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 6.50E+3nM
Assay Description:
Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...
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Target
5-hydroxytryptamine receptor 7
(GUINEA PIG)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1A/1B/1D/2C
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
Trypanothione reductase
(Trypanosoma cruzi)
University Of Manchester
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 2.30E+4nM
Assay Description:
Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)
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Target
Calcium-dependent protein kinase 4
(Plasmodium falciparum (isolate 3D7))
TBA
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
Ki: 1.50E+5nM
Assay Description:
Inhibition of Plasmodium falciparum His-tagged CDPK4 expressed in Escherichia coli BL21(DE3) using EGTA as substrate after 10 mins in presence of ATP
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
IC50: 16nM
Assay Description:
Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperone
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Copy SMILES
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Affinity Data
IC50: 350nM
Assay Description:
In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101
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Target
Genome polyprotein
(Hepatitis C virus)
University Of Wollongong
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 700nM
Assay Description:
Inhibitory concentration against hepatitis C virus helicase; range 0.6-0.7
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Target
Calmodulin-1
(Human)
Camp4 Therapeutics
US Patent
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 1.06E+3nM
Assay Description:
The competition binding assay was performed in a 384-well plate format and in 20 μl reactions. Serial dilutions (0.001-100 μM) of a test co...
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Target
Calmodulin-1
(Human)
Camp4 Therapeutics
US Patent
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 1.06E+3nM
Assay Description:
The competition binding assay was performed in a 384-well plate format and in 20 μl reactions. Serial dilutions (0.001-100 μM) of a test co...
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Target
Calmodulin-1
(Human)
Camp4 Therapeutics
US Patent
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 1.11E+3nM
Assay Description:
The competition binding assay was performed in a 384-well plate format and in 20 μl reactions. Serial dilutions (0.001-100 μM) of a test co...
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Target
Pleiotropic ABC efflux transporter of multiple drugs
(Saccharomyces cerevisiae S288c)
Wroclaw Medical University
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay
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Target
Sodium channel protein type 1/2/3 subunit alpha
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 6.30E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 7.20E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells
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Target
Beta-glucuronidase
(Rattus norvegicus)
Kaohsiung Medical University
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 7.80E+3nM
Assay Description:
Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CB
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Target
WD repeat-containing protein 48
(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 8.00E+3nM
Assay Description:
Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay
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Target
Lysozyme C-1
(Rattus norvegicus)
Kaohsiung Medical University
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 9.00E+3nM
Assay Description:
Inhibitory effect of compound on the release of lysozyme in rat neutrophils stimulated with fMLP/CB
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: <1.00E+4nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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IC50: <1.00E+4nM
Assay Description:
Inhibition of recombinant human BSEP expressed in baculovirus infected sf21 cell membrane vesicles assessed as reduction in ATP-dependent [3H]-tauroc...
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 1.09E+4nM
Assay Description:
TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells
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Target
NADPH oxidase 1
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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IC50: >1.70E+4nM
Assay Description:
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...
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Ubiquitin-conjugating enzyme E2 N
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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IC50: >2.00E+4nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...
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Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
(Oryctolagus cuniculus)
University Of Chemistry And Technology Prague
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Affinity Data
IC50: 4.50E+4nM
Assay Description:
Inhibition of rabbit skeletal muscle microsomes SERCA1a incubated for 10 mins by enzyme-coupled method
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Target
Protein kinase C zeta type
(Rattus norvegicus)
Purdue University
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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IC50: 7.36E+4nM
Assay Description:
Inhibition of rat brain PKC
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Target
DNA-dependent protein kinase catalytic subunit
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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IC50: 1.00E+5nM
Assay Description:
Inhibition of DNA-PK in human U1810 cells after 30 mins
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Protein kinase C zeta type
(Rattus norvegicus)
Purdue University
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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IC50: 5.00E+5nM
Assay Description:
Inhibition of protein kinase C
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Calmodulin
(Bos taurus)
Universit£
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Kd: 5.00E+3nM
Assay Description:
Binding affinity to dansylated bovine testes CaM by fluorescence analysis in presence of calcium2+
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Target
Albumin
(Rattus norvegicus)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Kd: 1.40E+4nM
Assay Description:
Binding affinity to Wistar rat serum albumin
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D(2) dopamine receptor
(Rattus norvegicus (rat))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Kd: 0.532nM
Assay Description:
Compound was tested for its effect on dopamine saturation analysis
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Calmodulin-1
(Human)
Camp4 Therapeutics
US Patent
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Kd: 1.00E+3nM
Assay Description:
Binding affinity to calmodulin (unknown origin)
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Calmodulin
(Bos taurus)
Universit£
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Kd: 3.40E+3nM
Assay Description:
Binding affinity to bovine brain CaM by FTPFACE analysis
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM79181
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
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Kd: 1.04nM
Assay Description:
Compound was tested for its effect on 5-hydroxytryptamine 2 receptor saturation analysis
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