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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

LigandPNGBDBM50330317(5-Methyl-1H-pyrrole-2-carboxylic acid (3R,4S,5R,6S...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Bharathiar University

Curated by ChEMBL
LigandPNGBDBM50330317(5-Methyl-1H-pyrrole-2-carboxylic acid (3R,4S,5R,6S...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in relaxation of pBR322 DNA by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50330317(5-Methyl-1H-pyrrole-2-carboxylic acid (3R,4S,5R,6S...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM50330317(5-Methyl-1H-pyrrole-2-carboxylic acid (3R,4S,5R,6S...)
Affinity DataIC50:  73nMAssay Description:Inhibition of Escherichia coli JM109 DNA gyrase subunit B assessed as ATP hydrolysis by ATPase assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Staphylococcus aureus)
Vit University

Curated by ChEMBL
LigandPNGBDBM50330317(5-Methyl-1H-pyrrole-2-carboxylic acid (3R,4S,5R,6S...)
Affinity DataIC50:  929nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase A expressed in Escherichia coli BL21(DE3) using relaxed pBR322 DNA as substrate incubated for 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50330317(5-Methyl-1H-pyrrole-2-carboxylic acid (3R,4S,5R,6S...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 decatenation activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA gyrase subunit B(Escherichia coli)
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50330317(5-Methyl-1H-pyrrole-2-carboxylic acid (3R,4S,5R,6S...)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to Escherichia coli GyrBMore data for this Ligand-Target Pair