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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Prolyl endopeptidase FAP
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM622247
(US20230312550, Example 207)
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Affinity Data
IC50: 0.170nM
Assay Description:
Table 1: Compounds were tested in a biochemical inhibition assay using hFAP enzyme at 0.24 nM FAC (Proteros, 38-760 (PR-0071)) and the substrate Ala-...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Presequence protease, mitochondrial
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM622247
(US20230312550, Example 207)
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Affinity Data
IC50: 430nM
Assay Description:
Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Prolyl endopeptidase FAP
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM622247
(US20230312550, Example 207)
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Copy InChI
Affinity Data
K
on
: 0.0000530M
-1
s
-1
Assay Description:
Table 1: Compounds were tested in a direct binding assay using 8K surface plasmon resonance biosensor (GE Healthcare) at 20° C. Immobilization of hFA...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Prolyl endopeptidase FAP
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM622247
(US20230312550, Example 207)
Copy SMILES
Copy InChI
Affinity Data
K
off
: 4.60E+6s
-1
Assay Description:
Table 1: Compounds were tested in a direct binding assay using 8K surface plasmon resonance biosensor (GE Healthcare) at 20° C. Immobilization of hFA...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Prolyl endopeptidase FAP
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM622247
(US20230312550, Example 207)
Copy SMILES
Copy InChI
Affinity Data
Kd: 0.0110nM
Assay Description:
Table 1: Compounds were tested in a biochemical inhibition assay using human Fibroblast activation protein alpha (hFAP) enzyme at 2.4 pM FAC (Protero...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI