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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University

US Patent
LigandPNGBDBM43220(4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol...)
Affinity DataIC50:  3.80E+3nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
German University

US Patent
LigandPNGBDBM43220(4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
German University

US Patent
LigandPNGBDBM43220(4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRas-related protein Rab-2A(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM43220(4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol...)
Affinity DataEC50:  704nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM43220(4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol...)
Affinity DataEC50:  8.04E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM43220(4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol...)
Affinity DataEC50:  8.04E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRas-related protein Rab-2A(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM43220(4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol...)
Affinity DataEC50:  704nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay