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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263488((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  218nM ΔG°:  -35.3kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263488((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  218nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263488((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  2.18E+5nMAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent