Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  50nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  47nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in CHO cells assessed as chloride transport by measuring membrane potential incubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  79nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator [1-507,509-1480](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  50nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  497nMAssay Description:Potentiation of CFTR G551D mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  39nMAssay Description:Potentiation of CFTR F508 deletion mutant (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskoli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  72nMAssay Description:Potentiation of wild type CFTR (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskolin and amilo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  113nMAssay Description:Potentiation of wild-type CFTR (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed