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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
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Target
Protein-serine O-palmitoleoyltransferase porcupine
(Homo sapiens (Human))
Experimental Therapeutics Centre
Curated by
ChEMBL
Ligand
BDBM50133864
(CHEMBL2139947 | US10251893, Compound 59)
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Affinity Data
IC50: 0.0740nM
Assay Description:
Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Protein Wnt-3a
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM50133864
(CHEMBL2139947 | US10251893, Compound 59)
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Affinity Data
IC50: <0.110nM
Assay Description:
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Protein-serine O-palmitoleoyltransferase porcupine
(Homo sapiens (Human))
Experimental Therapeutics Centre
Curated by
ChEMBL
Ligand
BDBM50133864
(CHEMBL2139947 | US10251893, Compound 59)
Copy SMILES
Copy InChI
Affinity Data
IC50: <1nM
Assay Description:
Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI