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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetProtein Wnt-3a(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM374916(N-(2,3'-bipyridin-6'-yl)-2-(2',3-dimethyl-2,4'-bip...)
Affinity DataIC50:  0.200nMAssay Description:Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM374916(N-(2,3'-bipyridin-6'-yl)-2-(2',3-dimethyl-2,4'-bip...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM374916(N-(2,3'-bipyridin-6'-yl)-2-(2',3-dimethyl-2,4'-bip...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed