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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Protein Wnt-3a
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM50133870
(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)
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Affinity Data
IC50: 0.380nM
Assay Description:
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
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US Patent
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Target
Protein-serine O-palmitoleoyltransferase porcupine
(Homo sapiens (Human))
Experimental Therapeutics Centre
Curated by
ChEMBL
Ligand
BDBM50133870
(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)
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Affinity Data
IC50: 0.400nM
Assay Description:
Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...
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UniProtKB/SwissProt
GoogleScholar
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CHEMBL
MCE
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Protein-serine O-palmitoleoyltransferase porcupine
(Homo sapiens (Human))
Experimental Therapeutics Centre
Curated by
ChEMBL
Ligand
BDBM50133870
(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.400nM
Assay Description:
Inhibition of porcupine (unknown origin)
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
GoogleScholar
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CHEMBL
MCE
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PC sid
PDB
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Protein-serine O-palmitoleoyltransferase porcupine
(Mus musculus)
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50133870
(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)
Copy SMILES
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Affinity Data
IC50: 0.400nM
Assay Description:
Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Protein-serine O-palmitoleoyltransferase porcupine
(Mus musculus)
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50133870
(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.400nM
Assay Description:
Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Protein-serine O-palmitoleoyltransferase porcupine
(Mus musculus)
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50133870
(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.900nM
Assay Description:
Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Protein-serine O-palmitoleoyltransferase porcupine
(Mus musculus)
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50133870
(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.900nM
Assay Description:
Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells after 48 hrs by Super-top flash reporter gene assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI