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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetMyc proto-oncogene protein(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human BRD4 (1 to 477 residues) measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human BRD3 measured by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human BRD2 measured by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50: <5nMAssay Description:All assay components were dissolved in buffer composition 20 mM Hepes pH 7.5, 150 mM NaCl, 5 mM DTT, 0.005% Tween 20, and 100 ug/ml BSA for BRD4 (1-4...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM296947(2-[3-(Dimethyl-1H-1,2,3-triazol-5-yl)-5-[oxan-4-yl...)
Affinity DataIC50: <5nMAssay Description:All assay components were dissolved in buffer composition 20 mM Hepes pH 7.5, 150 mM NaCl, 5 mM DTT, 0.005% Tween 20, and 100 ug/ml BSA for BRD4 (1-4...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM296947(2-[3-(Dimethyl-1H-1,2,3-triazol-5-yl)-5-[oxan-4-yl...)
Affinity DataIC50: <5nMAssay Description:All assay components were dissolved in buffer composition 20 mM Hepes pH 7.5, 150 mM NaCl, 5 mM DTT, 0.005% Tween 20, and 100 ug/ml BSA for BRD4 (1-4...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of human ERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human ERG by flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed