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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM622227(US20230312550, Example 187)
Affinity DataIC50:  0.0720nMAssay Description:Table 1: Compounds were tested in a biochemical inhibition assay using hFAP enzyme at 0.24 nM FAC (Proteros, 38-760 (PR-0071)) and the substrate Ala-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM622227(US20230312550, Example 187)
Affinity DataIC50:  0.0980nMAssay Description:Table 1: Compounds were tested in a direct binding assay using 8K surface plasmon resonance biosensor (GE Healthcare) at 20° C. Immobilization of hFA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPresequence protease, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM622227(US20230312550, Example 187)
Affinity DataIC50:  38nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM622227(US20230312550, Example 187)
Affinity DataKd:  0.0700nMAssay Description:Table 1: Compounds were tested in a biochemical inhibition assay using human Fibroblast activation protein alpha (hFAP) enzyme at 2.4 pM FAC (Protero...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM622227(US20230312550, Example 187)
Affinity DataKoff:  3.10E+6s-1Assay Description:Table 1: Compounds were tested in a direct binding assay using 8K surface plasmon resonance biosensor (GE Healthcare) at 20° C. Immobilization of hFA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM622227(US20230312550, Example 187)
Affinity DataKon:  0.000220M-1s-1Assay Description:Table 1: Compounds were tested in a direct binding assay using 8K surface plasmon resonance biosensor (GE Healthcare) at 20° C. Immobilization of hFA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent