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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18197(1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H...)
Affinity DataKi:  4nM ΔG°:  -49.9kJ/mole EC50:  3.5nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18197(1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H...)
Affinity DataKi:  5.30E+3nM ΔG°:  -28.0kJ/molepH: 7.4 T: 2°CAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18197(1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H...)
Affinity DataKi:  9.20E+3nM ΔG°:  -26.7kJ/molepH: 7.4 T: 2°CAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed