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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 13 hits in this display   

TargetProstaglandin E2 receptor EP2 subtype(Mus musculus (Mouse))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Mus musculus (Mouse))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP1 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP3 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50:  3.00E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human IP receptor assessed as LTD4-mediated intracellular calcium mobilization by cell-based aequorin luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human TP receptor assessed as LTD4-mediated intracellular calcium mobilization by call-based aequorin luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human CRTH2 receptor assessed as LTD4-mediated intracellular calcium mobilization by cell-based aequorin luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50092616(CHEMBL3586360)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human DP receptor assessed as LTD4-mediated intracellular calcium mobilization by cell-based aequorin luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed