Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
10
hits in this display
Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of Chk1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of CHK1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of Chk1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cyclin-dependent kinase 2-associated protein 1
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.10E+3nM
Assay Description:
Inhibition of Cdk1
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >3.16E+4nM
Assay Description:
Inhibition of human ERG
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >3.16E+4nM
Assay Description:
Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrest
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 19nM
Assay Description:
Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by patch clamp assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 450nM
Assay Description:
Inhibition of CHK1 in human HT29 cells assessed as check point abrogation
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50243258
((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 20nM
Assay Description:
Inhibition of CHK1 in human HT29 cells assessed as abrogation of campothecin induced check point
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI