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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
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kcal/mol
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Found
58
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Target
Protein mono-ADP-ribosyltransferase PARP15 [460-656,Y598L]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 295nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 329nM
Assay Description:
Inhibition of full length recombinant His6-tagged PARP10 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...
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Target
Protein mono-ADP-ribosyltransferase PARP10 [809-1017]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 329nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 330nM
Assay Description:
Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 330nM
Assay Description:
Inhibition of PARP10 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 330nM
Assay Description:
Inhibition of human 6His-tagged PARP10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) cells by fluorescent based analysis
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Target
Protein mono-ADP-ribosyltransferase PARP10 [809-1017,R931A]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 597nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 600nM
Assay Description:
Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) R931A mutant expressed in Escherichia coli Rosetta2 (DE3) Rosetta2 (DE3) usin...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 640nM
Assay Description:
Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 646nM
Assay Description:
Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.32E+3nM
Assay Description:
Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.35E+3nM
Assay Description:
Inhibition of PARP10 in human HeLa cells assessed as increase in cell colonies incubated for 10 days with replacement with fresh medium for every 4 d...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.35E+3nM
Assay Description:
Inhibition of ARTD10 (unknown origin)-induced cell death expressed in human HeLa cells after 10 days by methylene blue staining based colony formatio...
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Target
Protein mono-ADP-ribosyltransferase PARP14 [1535-1801,Y1660L]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 1.63E+3nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP11
(Homo sapiens)
Oregon Health And Science University
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 2.09E+3nM
Assay Description:
Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...
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Target
Protein mono-ADP-ribosyltransferase PARP11
(Homo sapiens)
Oregon Health And Science University
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10E+3nM
Assay Description:
Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...
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Target
Protein mono-ADP-ribosyltransferase PARP10 [809-1017,S927A]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 2.25E+3nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP10 [809-1017,L926Y]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 3.84E+3nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP16 [1-280]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 4.17E+3nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.17E+3nM
Assay Description:
Inhibition of full length recombinant His6-tagged PARP15 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...
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Target
Protein mono-ADP-ribosyltransferase PARP16
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 4.20E+3nM
Assay Description:
Inhibition of N-terminal His-tagged human ARTD15 (1 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) after 24 hrs in presence of NAD+
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of full length recombinant His6-tagged human PARP14 WWA/catalytic domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins ...
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of full length recombinant His6-tagged human PARP14 WWA/catalytic domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins ...
More data for this Ligand-Target Pair
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Target
Protein mono-ADP-ribosyltransferase PARP15 [460-656]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP15 (unknown origin)
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PARP15 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
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Target
Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD12 (469 to 701 residues) expressed in Escherichia coli Rosetta2 (DE3) after 20 hrs in...
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of N-terminal His-tagged human ARTD7 (482 to 678 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 3 h...
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Target
Protein mono-ADP-ribosyltransferase PARP4 [250-565]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 2.26E+4nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP14 [1535-1801]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 2.30E+4nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 2.30E+4nM
Assay Description:
Inhibition of PARP14 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.30E+4nM
Assay Description:
Inhibition of PARP14 (unknown origin)
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.30E+4nM
Assay Description:
Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD8 (1535 to 1801 residues) expressed in Escherichia coli Rosetta2 (DE3) after 21 hrs i...
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: 2.30E+4nM
Assay Description:
Inhibition of N-terminal His-tagged human ARTD4 (250 to 565 residues) expressed in Escherichia coli Rosetta2 (DE3) using TCEP as substrate after 2.5 ...
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Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: 2.34E+4nM
Assay Description:
Inhibition of full length recombinant His6-tagged PARP14 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of N-terminal His-tagged Z-basic-fused human ARTD6 (873 to 1161 residues) expressed in Escherichia coli Rosetta2 (DE3) using TCEP as subst...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of full length recombinant His6-tagged PARP5B catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of N-terminal His-tagged human ARTD1 (1 to 1014 residues) expressed in Escherichia coli Rosetta2 (DE3) using activated DNA as substrate af...
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of N-terminal His-tagged human ARTD5 (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) using TCEP as substrate after 18...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of full length recombinant His6-tagged PARP2 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence bas...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of full length recombinant His6-tagged PARP5A catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of full length recombinant His6-tagged PARP1 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence bas...
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Target
Protein mono-ADP-ribosyltransferase PARP12 [489-701]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target
Poly [ADP-ribose] polymerase tankyrase-2 [873-1161]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase tankyrase-1 [1030-1317]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Protein mono-ADP-ribosyltransferase PARP3 [R100H]
(Homo sapiens (Human))
University of Oulu
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
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Target Info
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of TNKS1 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of PARP2 (unknown origin)
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of TNKS2 (unknown origin)
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of PARP2 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of TNKS2 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of PARP1 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD3 (1 to 533 residues) expressed in Escherichia coli Rosetta2 (DE3) using DNA as subst...
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Mcdaniel College
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD2 (1 to 583 residues) expressed in Escherichia coli Rosetta2 (DE3) using activated DN...
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of full length recombinant His6-tagged human PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM199181
(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
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